dUTP + H2O => dUMP + pyrophosphate

Stable Identifier
R-HSA-73666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate
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Deoxyuridine triphosphatase (DUT) catalyzes the hydrolysis of dUTP to form dUMP and pyrophosphate. Two isoforms of DUT are expressed, generated by alternative splicing. The major one, annotated here, is localized to the nucleoplasm (Ladner et al. 1996). The enzyme is a homotrimer (Mol et al. 1996). In the cell, this reaction depletes the supply of dUTP, preventing its incorporation into DNA, while generating dUMP, the immediate precursor of thymidine nucleotides.

Literature References
PubMed ID Title Journal Year
8805593 Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

Mol, CD, Harris, JM, McIntosh, EM, Tainer, JA

Structure 1996
8631816 Characterization of distinct nuclear and mitochondrial forms of human deoxyuridine triphosphate nucleotidohydrolase

Ladner, RD, McNulty, DE, Carr, SA, Roberts, GD, Caradonna, SJ

J Biol Chem 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
dUTP diphosphatase activity of DUT trimer [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created