thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+

Stable Identifier
R-HSA-73646
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
regeneration of active (reduced) Thioredoxin
ReviewStatus
5/5
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thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
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Cytosolic thioredoxin reductase catalyzes the reaction of thioredoxin, oxidized and NADPH + H+ to form thioredoxin, reduced and NADP+ (Urig et al. 2006).
Literature References
PubMed ID Title Journal Year
16750198 Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity

Lieske, J, Urig, S, Irmler, A, Fritz-Wolf, K, Becker, K

FEBS Lett 2006
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Catalyst Activity

thioredoxin-disulfide reductase (NADPH) activity of TNXRD1:FAD dimer [cytosol]

Physical Entity
TNXRD1:FAD dimer [cytosol] (Homo sapiens)
Activity
thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)
Orthologous Events
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Bos taurus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Caenorhabditis elegans)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Gallus gallus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Mus musculus)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Plasmodium falciparum)
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+ (Rattus norvegicus)
Authored
Jassal, B  (2003-06-17)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Jassal, B  (2003-06-17)
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