Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
RRM1 [cytosol]
Stable Identifier
R-HSA-73638
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ribonucleotide reductase M1 polypeptide, Ribonucleoside-diphosphate reductase M1 chain (EC 1.17.4.1) (Ribonucleotide reductase large chain), Ribonucleoside-diphosphate reductase M1 chain , Ribonucleotide reductase large chain
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
RNR (M1M2) [cytosol] (Homo sapiens)
RRM1 dimer [cytosol] (Homo sapiens)
RRM1 [cytosol] (Homo sapiens)
RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
RNR (M1M2) [cytosol] (Homo sapiens)
RRM1 dimer [cytosol] (Homo sapiens)
RRM1 [cytosol] (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (glutaredoxin) (Homo sapiens)
RNR (M1M2B) [cytosol] (Homo sapiens)
RRM1 dimer [cytosol] (Homo sapiens)
RRM1 [cytosol] (Homo sapiens)
RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin) (Homo sapiens)
RNR (M1M2B) [cytosol] (Homo sapiens)
RRM1 dimer [cytosol] (Homo sapiens)
RRM1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23921 RRM1
Gene Names
RRM1, RR1
Chain
chain:1-792
Reference Genes
BioGPS Gene:6240 RRM1
COSMIC (genes):RRM1 RRM1
CTD Gene:6240 RRM1
dbSNP Gene:6240 RRM1
ENSEMBL:ENSG00000167325 RRM1
HGNC:10451 RRM1
KEGG:hsa:6240 RRM1
Monarch:6240 RRM1
NCBI Gene:6240 RRM1
OMIM:180410 RRM1
UCSC:P23921 RRM1
Reference Transcript
RefSeq:NM_001033.4 RRM1
RefSeq:NM_001318064.1 RRM1
RefSeq:NM_001318065.1 RRM1
Other Identifiers
11743602_a_at
11743603_a_at
11743604_s_at
11750667_a_at
16721126
201476_PM_s_at
201476_s_at
201477_PM_s_at
201477_s_at
3318010
3318016
3318017
3318019
3318020
3318021
3318022
3318023
3318024
3318025
3318026
3318027
3318028
3318029
3318030
3318031
3318032
3318033
3318034
3318035
3318036
3318037
3318038
3318039
3318040
3318041
3318042
3318043
3318044
3318045
3318047
34314_at
6240
7937915
A_23_P87351
GE59845
GO:0000731
GO:0003824
GO:0004748
GO:0005515
GO:0005524
GO:0005635
GO:0005737
GO:0005739
GO:0005829
GO:0005971
GO:0006206
GO:0006260
GO:0006264
GO:0006281
GO:0008584
GO:0009185
GO:0009263
GO:0009265
GO:0010212
GO:0010971
GO:0016020
GO:0016491
GO:0017076
GO:0021846
GO:0022414
GO:0042802
GO:0042995
GO:0043025
GO:0043226
GO:0048856
GO:0051290
GO:0055086
GO:0060041
GO:0061731
GO:0065003
GO:0070318
GO:0097718
GO:1900087
GO:1901135
HMNXSV003057021
Hs.2934.0.A1_3p_a_at
ILMN_1771593
PH_hs_0018698
TC11000090.hg
X59543_at
g4506748_3p_a_at
Participates
as a component of
RRM1 dimer [cytosol] (Homo sapiens)
Inferred To
Rrm1 [cytosol]
(Rattus norvegicus)
RRM1 [cytosol]
(Bos taurus)
RRM1 [cytosol]
(Caenorhabditis elegans)
RRM1 [cytosol]
(Canis familiaris)
RRM1 [cytosol]
(Danio rerio)
RRM1 [cytosol]
(Dictyostelium discoideum)
RRM1 [cytosol]
(Drosophila melanogaster)
RRM1 [cytosol]
(Mus musculus)
RRM1 [cytosol]
(Plasmodium falciparum)
RRM1 [cytosol]
(Saccharomyces cerevisiae)
RRM1 [cytosol]
(Schizosaccharomyces pombe)
RRM1 [cytosol]
(Sus scrofa)
rrm1 [cytosol]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2630
ENSEMBL
ENST00000300738
,
ENSP00000300738
OpenTargets
ENSG00000167325
HPA
ENSG00000167325-RRM1
ZINC - Substances
RIR1_HUMAN
ZINC target
P23921
PRO
P23921
Pharos - Targets
P23921
GlyGen
P23921
ZINC - Predictions - Purchasable
RIR1_HUMAN
HMDB Protein
HMDBP00108
PDB
2WGH
,
3HNE
,
3HND
,
3HNC
,
6AUI
,
6LKM
,
3HNF
,
6L7L
,
6L3R
,
4X3V
,
5TUS
,
5D1Y
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31350 RRM2
1
RRM2 [cytosol]
(R-HSA-73639)
0.85
7
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.527
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text