dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]

Stable Identifier
R-HSA-73635
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phosphorylation of dUMP or TMP to dUDP or TDP
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic deoxythymidylate kinase (DTYMK) catalyzes the reversible reaction of either dUMP or TMP with ATP to form dUDP or TDP. The active form of the enzyme is a homodimer (Lee and Cheng 1977).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

nucleoside monophosphate kinase activity of DTYMK dimer [cytosol]

Physical Entity
DTYMK dimer [cytosol] (Homo sapiens)
Activity
nucleoside monophosphate kinase activity (GO:0050145)
Orthologous Events
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Bos taurus)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Caenorhabditis elegans)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Canis familiaris)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Danio rerio)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Dictyostelium discoideum)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Drosophila melanogaster)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Gallus gallus)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Mus musculus)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Plasmodium falciparum)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Rattus norvegicus)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Saccharomyces cerevisiae)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Schizosaccharomyces pombe)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Sus scrofa)
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK] (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)
Cite Us!