Reactome | deamination of 2'-Deoxycytidine to 2'-Deoxyuridine

deamination of 2'-Deoxycytidine to 2'-Deoxyuridine

Stable Identifier

R-HSA-73608

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

cytidine + H2O + H(+) => uridine + NH4(+), 2'-deoxycytidine + H2O + H(+) => 2'-deoxyuridine + NH4(+), (deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)

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deamination of 2'-Deoxycytidine to 2'-Deoxyuridine

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Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
7923172	Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA Laliberte, J, Momparler, RL	Cancer Res	1994
15689149	Structure of human cytidine deaminase bound to a potent inhibitor Chung, SJ, Fromme, JC, Verdine, GL	J Med Chem	2005