(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)

Stable Identifier
R-HSA-73608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
deamination of 2'-Deoxycytidine to 2'-Deoxyuridine
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(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)
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Cytosolic cytidine deaminase catalyzes the hydrolysis of cytidine or dexoycytidine to form uridine or deoxyuridine and ammonia (Laliberte and Momparler 1994). The active form of the enzyme is a tetramer (Chung et al. 2005).

Literature References
PubMed ID Title Journal Year
7923172 Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA

Momparler, RL, Laliberte, J

Cancer Res 1994
15689149 Structure of human cytidine deaminase bound to a potent inhibitor

Fromme, JC, Chung, SJ, Verdine, GL

J Med Chem 2005
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Output
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as an event of
Catalyst Activity

cytidine deaminase activity of CDA tetramer [cytosol]

Physical Entity
CDA tetramer [cytosol] (Homo sapiens)
Activity
cytidine deaminase activity (GO:0004126)
Orthologous Events
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Bos taurus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Caenorhabditis elegans)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Canis familiaris)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Danio rerio)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Dictyostelium discoideum)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Drosophila melanogaster)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Gallus gallus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Mus musculus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Rattus norvegicus)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Saccharomyces cerevisiae)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Schizosaccharomyces pombe)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Sus scrofa)
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA) (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2003-06-17)
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