dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

Stable Identifier
R-HSA-73605
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
conversion of dUMP to dTMP
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Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).

Literature References
PubMed ID Title Journal Year
2656695 Expression of human thymidylate synthase in Escherichia coli

Sirawaraporn, W, Santi, DV, Davisson, VJ

J Biol Chem 1989
11278511 Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

Lebioda, L, Berger, SH, Minor, W, Phan, J, Steadman, DJ, Ding, WC, Koli, S, Dunlap, RB

J Biol Chem 2001
Participants
Participates
Catalyst Activity

thymidylate synthase activity of TS dimer [cytosol]

Orthologous Events
Created
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