dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

Stable Identifier
R-HSA-73605
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Synonyms
conversion of dUMP to dTMP
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dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate
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Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).

Literature References
PubMed ID Title Journal Year
2656695 Expression of human thymidylate synthase in Escherichia coli

Sirawaraporn, W, Santi, DV, Davisson, VJ

J Biol Chem 1989
11278511 Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

Lebioda, L, Berger, SH, Minor, W, Phan, J, Steadman, DJ, Ding, WC, Koli, S, Dunlap, RB

J Biol Chem 2001
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Catalyst Activity

thymidylate synthase activity of TS dimer [cytosol]

Physical Entity
TS dimer [cytosol] (Homo sapiens)
Activity
thymidylate synthase activity (GO:0004799)
Orthologous Events
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Bos taurus)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Caenorhabditis elegans)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Canis familiaris)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Danio rerio)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Drosophila melanogaster)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Mus musculus)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Plasmodium falciparum)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Rattus norvegicus)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Saccharomyces cerevisiae)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Schizosaccharomyces pombe)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Sus scrofa)
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate (Xenopus tropicalis)
Created
Jassal, B  (2003-06-17)
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