Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).
Phan, J, Steadman, DJ, Koli, S, Ding, WC, Minor, W, Dunlap, RB, Berger, SH, Lebioda, L
Davisson, VJ, Sirawaraporn, W, Santi, DV
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