Reactome | dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

Stable Identifier

R-HSA-73605

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

conversion of dUMP to dTMP

ReviewStatus

5/5

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dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

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Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
2656695	Expression of human thymidylate synthase in Escherichia coli Davisson, VJ, Sirawaraporn, W, Santi, DV	J Biol Chem	1989
11278511	Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors Phan, J, Steadman, DJ, Koli, S, Ding, WC, Minor, W, Dunlap, RB, Berger, SH, Lebioda, L	J Biol Chem	2001