dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

Stable Identifier
R-HSA-73605
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
conversion of dUMP to dTMP
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).
Literature References
PubMed ID Title Journal Year
2656695 Expression of human thymidylate synthase in Escherichia coli

Sirawaraporn, W, Santi, DV, Davisson, VJ

J Biol Chem 1989
11278511 Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors

Lebioda, L, Berger, SH, Minor, W, Phan, J, Steadman, DJ, Ding, WC, Koli, S, Dunlap, RB

J Biol Chem 2001
Participants
Participates
Catalyst Activity

thymidylate synthase activity of TS dimer [cytosol]

Orthologous Events
Created
Cite Us!