Cytosolic thymidylate synthase catalyzes the reaction of dUMP and N5,N10-methylene tetrahydrofolate to form TMP and dihydrofolate (Davisson et al. 1989). The enzyme is a homodimer (Phan et al. 2001).
Sirawaraporn, W, Santi, DV, Davisson, VJ
Lebioda, L, Berger, SH, Minor, W, Phan, J, Steadman, DJ, Ding, WC, Koli, S, Dunlap, RB
thymidylate synthase activity of TS dimer [cytosol]
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