Reactome | SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP

SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP

Stable Identifier

R-HSA-735702

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The human gene SLC35A2 encodes the UDP-galactose transporter (Miura et al. 1996). It is located on the Golgi membrane and mediates the antiport of UDP-Gal into the Golgi lumen in exchange for UMP. This transporter is also known to transport UDP-N-acetylgalactosamine (UDP-GalNAc) by the same antiport mechanism (Segawa et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
8889805	Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator Ishida, N, Miura, N, Ayusawa, D, Hara, T, Yamauchi, M, Kawakita, M, Hoshino, M	J Biochem	1996
11784306	Human and Drosophila UDP-galactose transporters transport UDP-N-acetylgalactosamine in addition to UDP-galactose Ishida, N, Segawa, H, Kawakita, M	Eur J Biochem	2002