Reactome | TK1 [cytosol]

TK1 [cytosol]

Stable Identifier

R-HSA-73500

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

thymidine kinase 1, soluble, Thymidine kinase, cytosolic (EC 2.7.1.21), Thymidine kinase, cytosolic

Locations in the PathwayBrowser for interactor UniProt:Q5RL73 RBM48

Expand all

External Reference Information

External Reference

UniProt:P04183 TK1

Gene Names

TK1

Chain

initiator methionine:1, chain:2-234

Reference Genes

BioGPS Gene:7083 TK1

COSMIC (genes):TK1 TK1

CTD Gene:7083 TK1

dbSNP Gene:7083 TK1

ENSEMBL:ENSG00000167900 TK1

HGNC:11830 TK1

KEGG Gene (Homo sapiens):7083 TK1

Monarch:7083 TK1

NCBI Gene:7083 TK1

OMIM:188300 TK1

UCSC:P04183 TK1

Reference Transcript

RefSeq:NM_003258.4 TK1

Other Identifiers

0004120180

00240+2.7.1.21

00983+2.7.1.21

11718127_at

11718128_x_at

1554408_a_at

16849379

1W4R

1XBT

202338_at

2ORV

2WVJ

3772159

3772160

3772161

3772162

3772163

3772165

3772166

3772167

3772168

3772169

3772170

3772172

3772173

41400_at

4683

7083

8018849

910_at

A0A384MDV9

A_23_P107421

A_24_P915535

AAA61187

AAA61189

AAA61191

AAH06484

AAH07872

AAH07986

AAP35587

ADO22386

AK314950

BAG37455

BC006484

BC007872

BC007986

BT006941

CAB004683

CCDS11754

ENSG00000167900

ENSP00000301634

ENST00000301634

ENST00000301634.11

EntrezGene:7083

EntrezGene:TK1

g4507518_3p_at

g4507518_3p_x_at

GE57538

GO:0000166

GO:0003674

GO:0004797

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0006139

GO:0006259

GO:0008150

GO:0008270

GO:0009058

GO:0009157

GO:0016301

GO:0016310

GO:0016740

GO:0022607

GO:0034641

GO:0042802

GO:0043097

GO:0043167

GO:0044281

GO:0046104

GO:0046872

GO:0051289

GO:0065003

GO:0071897

GQ891524

HGNC:11830

Hs2.105097.2.S1_3p_s_at

ILMN_1806037

IPR001267

IPR020633

IPR027417

K02581

K7ENW5

K7ERJ1

K7ERV3

K7ES52

M13643

M15205

M15205_at

MIM:188300

NM_003258

NP_003249

PF00265

PH_hs_0022775

PH_hs_0035630

TC17001914.hg

TK1

TK1-201

UPI000012DE94

Participant Of

hasComponent

TK1 tetramer [cytosol]

output

TK1 gene expression is stimulated by E2F1

Inferred To

TK1 [cytosol] (Bos taurus)

TK1 [cytosol] (Caenorhabditis elegans)

TK1 [cytosol] (Canis familiaris)

TK1 [cytosol] (Danio rerio)

TK1 [cytosol] (Dictyostelium discoideum)

TK1 [cytosol] (Gallus gallus)

TK1 [cytosol] (Mus musculus)

TK1 [cytosol] (Rattus norvegicus)

TK1 [cytosol] (Sus scrofa)

TK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_003249.3

OpenTargets

ENSG00000167900

IntEnz

2.7.1.21

GeneCards

P04183

ZINC target

P04183

PRO

P04183

HMDB Protein

HMDBP03814

PDB

1XBT, 1W4R, 2WVJ, 2ORV

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.592	2
UniProt:Q1RN33 Q1RN33			0.556	3
UniProt:Q14194 CRMP1	4	CRMP1 [cytosol] (R-HSA-398120) p-Y-CRMP1 [cytosol] (R-HSA-399784) p-T509,T514,S518,S522-CRMP1 [cytosol] (R-HSA-399777) p-S522-CRMP1 [cytosol] (R-HSA-399779)	0.553	2
UniProt:Q04724 TLE1	2	TLE1 [nucleoplasm] (R-HSA-212327) Ub-TLE1 [nucleoplasm] (R-HSA-3322369)	0.553	2
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.553	2
UniProt:Q9GZT6 CC90B			0.553	2
UniProt:Q13432 U119A			0.553	2
UniProt:P51693 APLP1			0.553	2
UniProt:Q5RL73 RBM48			0.553	2
UniProt:O60383 GDF9			0.553	2
UniProt:Q9UKR5 ERG28			0.553	2
UniProt:Q13885 TUBB2A	6	TUBB2A unfolded [cytosol] (R-HSA-392776) TUBB2A folding intermediate [cytosol] (R-HSA-392802) Polyglycyl-TUBB2A [cytosol] (R-HSA-8867466) Polyglutamyl-TUBB2A [cytosol] (R-HSA-8867392) TUBB2A [axonemal microtubule] (R-HSA-5610431) TUBB2A [cytosol] (R-HSA-191699)	0.553	2
UniProt:Q15047 SETDB1	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.553	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.553	2
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.553	2
UniProt:A0A087WZT3 A0A087WZT3			0.488	2