Reactome | SLC29A3 transports nucleosides from lysosomal lumen to cytosol

SLC29A3 transports nucleosides from lysosomal lumen to cytosol

Stable Identifier

R-HSA-727749

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lysosomal membrane, lysosomal lumen

Synonyms

Equilibrative transport (export) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3

ReviewStatus

5/5

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SLC29A3 transports nucleosides from lysosomal lumen to cytosol

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The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18940313	The H syndrome is caused by mutations in the nucleoside transporter hENT3 Molho-Pessach, V, Lerer, I, Abeliovich, D, Agha, Z, Abu Libdeh, A, Broshtilova, V, Elpeleg, O, Zlotogorski, A	Am J Hum Genet	2008
15701636	Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes Baldwin, SA, Yao, SY, Hyde, RJ, Ng, AM, Foppolo, S, Barnes, K, Ritzel, MW, Cass, CE, Young, JD	J Biol Chem	2005