SLC29A3 transports nucleosides from lysosomal lumen to cytosol

Stable Identifier
R-HSA-727749
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Equilibrative transport (export) of nucleosides and adenine by solute carrier family 29 (nucleoside transporters), member 3
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The human gene SLC29A3 encodes the equilibrative nucleoside transporter 3 (ENT3). It is abundant in many tissues, especially the placenta and is localized intracellularly on the lysosomal membrane. SLC29A3 mediates the reversible transport of nucleosides and the nucleobase adenine (Baldwin et al. 2005). Defects in SLC29A3 can cause histiocytosis-lymphadenopathy plus syndrome (HLAS; MIM:602782), an autosomal recessive disorder characterised by combined features from 2 or more of four histiocytic disorders (Molho-Pessach et al. 2008).
Literature References
PubMed ID Title Journal Year
18940313 The H syndrome is caused by mutations in the nucleoside transporter hENT3

Molho-Pessach, V, Elpeleg, O, Lerer, I, Abeliovich, D, Broshtilova, V, Agha, Z, Abu Libdeh, A, Zlotogorski, A

Am J Hum Genet 2008
15701636 Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

Ritzel, MW, Foppolo, S, Hyde, RJ, Ng, AM, Barnes, K, Baldwin, SA, Young, JD, Cass, CE, Yao, SY

J Biol Chem 2005
Participants
Participates
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A3 [lysosomal membrane]

Orthologous Events
Cross References
Authored
Reviewed
Created
Cite Us!