Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

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R-HSA-72662
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Pathway
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Homo sapiens
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The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA.

Literature References
PubMed ID Title Journal Year
6853548 New initiation factor activity required for globin mRNA translation.

Tahara, SM, Morgan, MA, Grifo, JA, Merrick, WC, Shatkin, AJ

J Biol Chem 1983
592399 Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors.

Erni, B, Schreier, MH, Trachsel, H, Staehelin, T

J Mol Biol 1978
641056 The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

Benne, R, Hershey, JW

J Biol Chem 1978
9732867 Eukaryotic ribosomes require initiation factors 1 and 1A to locate initiation codons.

Hellen, CU, Pestova, TV, Borukhov, SI

Nature 1999
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