eIF4F binds to mRNP

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The factor eIF4E within the eIF4F (cap-binding) complex directly binds the 5'-cap on eukaryotic mRNAs. Note that the mRNA is in complex with cytoplasmic proteins constituting an mRNP complex.

Literature References
PubMed ID Title Journal Year
291969 Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.

Sonenberg, N, Rupprecht, KM, Hecht, SM, Shatkin, AJ

Proc Natl Acad Sci U S A 1980
6853548 New initiation factor activity required for globin mRNA translation.

Grifo, JA, Tahara, SM, Morgan, MA, Shatkin, AJ, Merrick, WC

J Biol Chem 1983
Participant Of
Cite Us!