eIF4F binds to mRNP

Stable Identifier
R-HSA-72635
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The factor eIF4E within the eIF4F (cap-binding) complex directly binds the 5'-cap on eukaryotic mRNAs. Note that the mRNA is in complex with cytoplasmic proteins constituting an mRNP complex.

Literature References
PubMed ID Title Journal Year
291969 Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP.

Sonenberg, N, Rupprecht, KM, Hecht, SM, Shatkin, AJ

Proc Natl Acad Sci U S A 1980
6853548 New initiation factor activity required for globin mRNA translation.

Grifo, JA, Tahara, SM, Morgan, MA, Shatkin, AJ, Merrick, WC

J Biol Chem 1983
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