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eIF4F [cytosol]
Stable Identifier
R-HSA-72587
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
cap-binding complex
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Formation of the cap-binding eIF4F complex (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4F binds to mRNP (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
eIF4F [cytosol] (Homo sapiens)
Participants
components
eIF4A subunits complex [cytosol] (Homo sapiens)
EIF4E [cytosol] (Homo sapiens)
EIF4G1 [cytosol] (Homo sapiens)
Participant Of
hasComponent
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol]
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol]
48S complex [cytosol]
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol]
eIF4F:mRNP [cytosol]
mRNA:eIF4F:eIF4B:eIF4H [cytosol]
input
eIF4F binds to mRNP
output
Formation of the cap-binding eIF4F complex
Inferred To
eIF4F [cytosol] (Caenorhabditis elegans)
eIF4F [cytosol] (Canis familiaris)
eIF4F [cytosol] (Danio rerio)
eIF4F [cytosol] (Dictyostelium discoideum)
eIF4F [cytosol] (Drosophila melanogaster)
eIF4F [cytosol] (Gallus gallus)
eIF4F [cytosol] (Mus musculus)
eIF4F [cytosol] (Plasmodium falciparum)
eIF4F [cytosol] (Rattus norvegicus)
eIF4F [cytosol] (Saccharomyces cerevisiae)
eIF4F [cytosol] (Schizosaccharomyces pombe)
eIF4F [cytosol] (Sus scrofa)
eIF4F [cytosol] (Xenopus tropicalis)
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