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EIF3G [cytosol]
Stable Identifier
R-HSA-72538
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3-delta, eIF-3 delta, eIF3g, eIF3 p44, eIF3 p42, eukaryotic translation initiation factor 3 subunit 4, Eukaryotic translation initiation factor 3 subunit 4, eIF-3 RNA-binding subunit
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3G [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75821 EIF3G
Gene Names
EIF3G, EIF3S4
Chain
initiator methionine:, chain:2-320
Reference Genes
BioGPS Gene:8666 EIF3G
COSMIC (genes):EIF3G EIF3G
CTD Gene:8666 EIF3G
dbSNP Gene:8666 EIF3G
ENSEMBL:ENSG00000130811 EIF3G
ENSEMBL_homo_sapiens_GENE:ENSG00000130811.12 EIF3G
HGNC:3274 EIF3G
KEGG Gene (Homo sapiens):8666 EIF3G
Monarch:8666 EIF3G
NCBI Gene:8666 EIF3G
OMIM:603913 EIF3G
UCSC:O75821 EIF3G
Reference Transcript
RefSeq:NM_003755.4 EIF3G
Other Identifiers
11743126_a_at
11748295_a_at
16868564
208887_PM_at
208887_at
34302_at
3850041
3850042
3850043
3850044
3850045
3850048
3850050
3850054
3850055
3850058
3850060
3850062
8033899
8666
A_23_P38887
A_33_P3369581
GE54165
GO:0001732
GO:0002181
GO:0002183
GO:0003676
GO:0003723
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0016282
GO:0033290
GO:0045182
GO:0048471
GO:0065003
GO:0075525
HMNXSV003007041
ILMN_1689446
PH_hs_0002463
TC19001158.hg
g12653882_3p_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
eif3G [cytosol]
(Dictyostelium discoideum)
TIF35 [cytosol]
(Saccharomyces cerevisiae)
Eif3g [cytosol]
(Mus musculus)
Eif3g [cytosol]
(Rattus norvegicus)
eif-3.G [cytosol]
(Caenorhabditis elegans)
EIF3G [cytosol]
(Bos taurus)
EIF3G [cytosol]
(Canis familiaris)
EIF3G [cytosol]
(Gallus gallus)
EIF3G [cytosol]
(Plasmodium falciparum)
EIF3G [cytosol]
(Sus scrofa)
eIF3g1 [cytosol]
(Drosophila melanogaster)
tif35 [cytosol]
(Schizosaccharomyces pombe)
eif3g [cytosol]
(Danio rerio)
eif3g [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003746.2
OpenTargets
ENSG00000130811
GeneCards
O75821
HPA
ENSG00000130811-EIF3G
Ensembl
ENSG00000130811
,
ENST00000253108
,
ENSP00000253108
PRO
O75821
Pharos - Targets
O75821
PDB
2MJC
,
7QP7
,
6ZMW
,
8PPL
,
6YBS
,
8OZ0
,
2CQ0
,
7QP6
,
5K0Y
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
6
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