Reactome | RPS6 [cytosol]

RPS6 [cytosol]

Stable Identifier

R-HSA-72381

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

40S small ribosomal protein 6, P10660, 40S ribosomal protein S6, Phosphoprotein NP33

Locations in the PathwayBrowser for interactor UniProt:Q9Y676 MRPS18B

Expand all

External Reference Information

External Reference

UniProt:P62753 RPS6

Gene Names

RPS6, OK/SW-cl.2

Chain

chain:1-249

Reference Genes

BioGPS Gene:6194 RPS6

COSMIC (genes):RPS6 RPS6

CTD Gene:6194 RPS6

dbSNP Gene:6194 RPS6

ENSEMBL:ENSG00000137154 RPS6

ENSEMBL_homo_sapiens_GENE:ENSG00000137154.13 RPS6

HGNC:10429 RPS6

KEGG Gene (Homo sapiens):6194 RPS6

Monarch:6194 RPS6

NCBI Gene:6194 RPS6

OMIM:180460 RPS6

UCSC:P62753 RPS6

Reference Transcript

RefSeq:NM_001010.2 RPS6

Other Identifiers

11719464_x_at

11763007_x_at

17092737

18670421

18670422

18670423

18670425

18670426

18670429

18670432

200081_PM_s_at

200081_s_at

201254_PM_x_at

201254_x_at

209134_PM_s_at

209134_s_at

3200714

3200715

3200716

3200718

3200719

3200724

3200725

3200726

3200728

3200733

35125_at

3822012

4012811

6194

8160308

91667_at

A_23_P123563

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006364

GO:0006412

GO:0008284

GO:0012501

GO:0015935

GO:0016020

GO:0019901

GO:0022626

GO:0022627

GO:0023052

GO:0030425

GO:0031929

GO:0032040

GO:0036464

GO:0042254

GO:0042274

GO:0042593

GO:0043065

GO:0043226

GO:0044297

GO:1990904

HMNXSV003054392

ILMN_1656791

ILMN_1808939

M77232_rna1_at

PH_hs_0030081

PH_hs_0039702

TC09000936.hg

TC09000938.hg

g12751054_3p_s_at

Participates

as an input of

as a component of

40S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

RPS6 [nucleoplasm]

3OHR147-RPS6 [cytosol]

p-5S-RPS6 [cytosol]

Inferred To

RPS6A [cytosol] (Saccharomyces cerevisiae)

rps602 [cytosol] (Schizosaccharomyces pombe)

RPS6 [cytosol] (Bos taurus)

RPS6 [cytosol] (Canis familiaris)

RPS6 [cytosol] (Gallus gallus)

RPS6 [cytosol] (Plasmodium falciparum)

RPS6 [cytosol] (Sus scrofa)

Homologues of RPS6 [cytosol] (Saccharomyces cerevisiae)

RPS6B [cytosol] (Saccharomyces cerevisiae)

rps6 [cytosol] (Danio rerio)

rps6 [cytosol] (Dictyostelium discoideum)

rps6 [cytosol] (Xenopus tropicalis)

RpS6 [cytosol] (Drosophila melanogaster)

rps-6 [cytosol] (Caenorhabditis elegans)

Rps6 [cytosol] (Mus musculus)

Rps6 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001001.2

OpenTargets

ENSG00000137154

GeneCards

P62753

HPA

ENSG00000137154-RPS6

Ensembl

ENST00000380394, ENSP00000369757, ENSG00000137154

PRO

P62753

Pharos - Targets

P62753

PDB

6G5H, 5A2Q, 8JDJ, 6Y2L, 8JDL, 6XA1, 5OA3, 6ZP4, 6ZV6, 6Y0G, 5AJ0, 7MQA, 7MQ8, 5LKS, 8G5Z, 6ZXF, 7WU0, 7WTW, 6ZMT, 6ZXD, 6G18, 4V6X, 6Z6L, 6G4S, 7QP6, 6OM7, 7WTU, 6Z6M, 6ZMW, 6ZLW, 7XNY, 6G5I, 6IP6, 6QZP, 7K5I, 6IP8, 4UG0, 7WTZ, 6F4P, 6G51, 6G4W, 7WTV, 7MQ9, 6ZXH, 8OZ0, 6ZON, 6G53, 6ZUO, 6OM0, 8PPK, 7ZJX, 7A09, 6OLZ, 6Y57, 5VYC, 8PPL, 8G5Y, 6ZOK, 6IP5, 7XNX, 6ZMO, 8T4S, 6OLG, 8GLP, 7QVP, 6F4Q, 6ZMI, 8G6J, 7R4X, 8Y0X, 8IFD, 5T2C, 7WTX, 6YBW, 6ZVJ, 8JDM, 7ZJW, 6ZOJ, 8G60, 6OLI, 8JDK, 6FEC, 5FLX, 6OLF, 8IFE, 6ZME, 6Z6N, 6ZXG, 7QP7, 6OLE, 7TQL, 8Y0W, 6ZVH, 7WTS, 7WTT, 8G61, 6ZM7, 6ZXE, 6ZN5

Interactors (134)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95793 STAU1			0.766	8
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.706	5
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.702	6
UniProt:Q14684 RRP1B			0.671	5
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.65	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.615	3
UniProt:Q15397 PUM3			0.615	5
UniProt:Q5C9Z4 NOM1			0.615	3
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.615	5
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.615	3
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.615	3
UniProt:Q2NL82 TSR1	2	TSR1 [nucleoplasm] (R-HSA-6791574) TSR1 [cytosol] (R-HSA-6791570)	0.615	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.576	3
UniProt:P82675 MRPS5	1	MRPS5 [mitochondrial inner membrane] (R-HSA-5368176)	0.569	3
UniProt:Q8N9T8 KRI1			0.569	5
UniProt:Q9BZE4 GTPB4			0.569	4
UniProt:Q5SSJ5 HP1B3			0.569	3
UniProt:Q13084 MRPL28	1	MRPL28 [mitochondrial inner membrane] (R-HSA-5368246)	0.569	3
UniProt:Q5JTH9 RRP12			0.569	5
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.569	3
UniProt:Q9Y676 MRPS18B	1	MRPS18B [mitochondrial inner membrane] (R-HSA-5368234)	0.569	3
UniProt:P82914 MRPS15	1	MRPS15 [mitochondrial inner membrane] (R-HSA-5368166)	0.569	4
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.569	5
UniProt:Q7L2E3 DHX30			0.569	5
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.569	4
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.569	3
UniProt:P82663 MRPS25	1	MRPS25 [mitochondrial inner membrane] (R-HSA-5368204)	0.569	3
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.569	3
UniProt:Q9BQG0 MYBBP1A	1	MYBBP1A [nucleoplasm] (R-HSA-5250650)	0.569	3
UniProt:Q96RG2 PASK			0.558	3
UniProt:P0DTD1-PRO_0000449619 REP			0.528	3
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.527	2
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:Q9Y2R9 MRPS7	1	MRPS7 [mitochondrial inner membrane] (R-HSA-5368191)	0.527	3
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	2
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.527	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	3
UniProt:Q96QR8 PURB			0.527	2
UniProt:Q14151 SAFB2			0.527	2
UniProt:O95373 IPO7			0.527	3
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.527	4
UniProt:O76021 RL1D1			0.483	2
UniProt:P62424 RPL7A	1	RPL7A [cytosol] (R-HSA-72488)	0.483	3
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.483	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.483	3
UniProt:Q9H116 GZF1			0.483	2
UniProt:Q96G21 IMP4	1	IMP4 [nucleoplasm] (R-HSA-6790690)	0.483	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.483	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.483	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.483	4
UniProt:Q9NX58 LYAR			0.483	2
UniProt:Q15050 RRS1			0.483	3
UniProt:P62899 RPL31	1	RPL31 [cytosol] (R-HSA-72454)	0.483	3
UniProt:Q5VWQ0 RSBN1			0.483	3
UniProt:O00566 MPHOSPH10	1	MPHOSPH10 [nucleoplasm] (R-HSA-6790661)	0.483	4
UniProt:Q9NWT1 PK1IP			0.483	2
UniProt:Q1ED39 KNOP1			0.483	3
UniProt:O00567 NOP56	2	NOP56 [nucleoplasm] (R-HSA-6790696) NOP56 [cytosol] (R-HSA-391293)	0.483	2
UniProt:O15381 NVL			0.483	2
UniProt:Q9H8H2 DDX31			0.483	2
UniProt:Q13823 NOG2			0.483	3
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.483	2
UniProt:Q14692 BMS1	1	BMS1 [nucleoplasm] (R-HSA-6790720)	0.483	3
UniProt:Q9ULW3 ABT1			0.483	2
UniProt:Q14690 PDCD11	1	PDCD11 [nucleoplasm] (R-HSA-6790646)	0.483	2
UniProt:Q9Y4C8 RBM19			0.483	4
UniProt:Q8WTT2 NOC3L			0.483	3
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.483	2
UniProt:Q6ZN17 LN28B			0.483	2
UniProt:Q9BRJ6 CG050			0.483	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.483	2
UniProt:O75683 SURF6			0.483	3
UniProt:O76094 SRP72	1	SRP72 [cytosol] (R-HSA-265069)	0.483	2
UniProt:P05386 RPLP1	1	RPLP1 [cytosol] (R-HSA-72398)	0.483	2
UniProt:O75569 PRKRA	2	p-S246,S287-PRKRA [cytosol] (R-HSA-9834791) PRKRA [cytosol] (R-HSA-2399897)	0.483	3
UniProt:Q6PK04 CC137			0.483	3
UniProt:Q9NVP1 DDX18			0.483	3
UniProt:Q96GQ7 DDX27			0.483	3
UniProt:Q49A26 GLYR1			0.483	3
UniProt:Q9NQ55 SSF1			0.483	4
UniProt:Q8NEJ9 NGDN			0.483	3
UniProt:P42696 RBM34			0.483	2
UniProt:Q9NZM5 NOP53			0.483	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.483	2
UniProt:P18621 RPL17	1	RPL17 [cytosol] (R-HSA-72418)	0.483	3
UniProt:Q9GZR2 REXO4			0.483	2
UniProt:Q9NVU7 SDA1			0.483	2
UniProt:O15226 NKRF			0.483	2
UniProt:P05387 RPLP2	1	RPLP2 [cytosol] (R-HSA-72400)	0.483	3
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.483	3
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.483	2
UniProt:Q9BYN8 MRPS26	1	MRPS26 [mitochondrial inner membrane] (R-HSA-5368265)	0.483	2
UniProt:Q8TDD1 DDX54			0.483	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10
UniProt:P46781 RPS9	2	RPS9 [nucleoplasm] (R-HSA-6790663) RPS9 [cytosol] (R-HSA-72387)	0.483	2
UniProt:Q96A35 MRPL24	1	MRPL24 [mitochondrial inner membrane] (R-HSA-5368177)	0.483	2
UniProt:Q9GZR7 DDX24			0.483	3
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.483	2
UniProt:Q9HAN9 NMNAT1	1	NMNAT1 [nucleoplasm] (R-HSA-200484)	0.483	2
UniProt:Q9BYG3 MK67I			0.483	2
UniProt:Q9BSC4 NOL10			0.483	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.483	3
UniProt:P19338 NCL	3	NCL [plasma membrane] (R-HSA-9836466) NCL [macropinosome membrane] (R-HSA-9837666) NCL [nucleoplasm] (R-HSA-6791213)	0.483	2
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.483	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.483	3
UniProt:Q9BQ39 DDX50			0.483	2
UniProt:Q9Y3U8 RPL36	1	RPL36 [cytosol] (R-HSA-72464)	0.483	2
UniProt:Q9H0A0 NAT10	1	NAT10 [nucleoplasm] (R-HSA-6791008)	0.483	3
UniProt:Q9NXF1 TEX10	1	TEX10 [nucleoplasm] (R-HSA-3826589)	0.483	2
UniProt:P62847 RPS24	2	RPS24 [nucleoplasm] (R-HSA-6791186) RPS24 [cytosol] (R-HSA-72355)	0.483	2
UniProt:Q6NW34 NEPRO			0.483	2
UniProt:Q9Y221 NIP7	1	NIP7 [nucleoplasm] (R-HSA-6797236)	0.483	2
UniProt:P62277 RPS13	2	RPS13 [nucleoplasm] (R-HSA-6791198) RPS13 [cytosol] (R-HSA-72331)	0.483	2
UniProt:P82664 MRPS10	2	MRPS10 [mitochondrial matrix] (R-HSA-9839687) MRPS10 [mitochondrial inner membrane] (R-HSA-5368190)	0.483	3
UniProt:Q9NY93 DDX56			0.483	3
UniProt:Q9NV31 IMP3	1	IMP3 [nucleoplasm] (R-HSA-6790664)	0.483	2
UniProt:Q13206 DDX10			0.483	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P40429 RPL13A	2	p-RPL13A [cytosol] (R-HSA-156829) RPL13A [cytosol] (R-HSA-72412)	0.483	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.483	4
UniProt:Q9H6F5 CCD86			0.483	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.483	2
UniProt:Q6DKI1 RL7L			0.483	3
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.483	3
UniProt:Q96GA3 LTV1	2	LTV1 [nucleoplasm] (R-HSA-6791566) LTV1 [cytosol] (R-HSA-6791520)	0.483	3
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.483	4
UniProt:P62917 RPL8	3	3OHH216-RPL8 [nucleoplasm] (R-HSA-9630976) RPL8 [nucleoplasm] (R-HSA-9630985) RPL8 [cytosol] (R-HSA-72490)	0.483	2
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.483	4
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.483	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:Q9BRP8 PYM1			0.462	2
UniProt:Q00005 2ABB			0.462	2

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