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mRNA [cytosol]
Stable Identifier
R-HSA-72323
Type
Genes and Transcripts [GenomeEncodedEntity]
Species
Homo sapiens
Compartment
cytosol
Synonyms
messenger RNA
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to starvation (Homo sapiens)
Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
IMPACT binds GCN1 (Homo sapiens)
GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
ISG15 antiviral mechanism (Homo sapiens)
Competitive inhibition of translation initiation by ISGylated 4EHP (Homo sapiens)
ISGylated 4EHP:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
eIF4F:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Selenoamino acid metabolism (Homo sapiens)
Selenocysteine synthesis (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Sec-tRNA(Sec):EEFSEC:GTP binds to 80S Ribosome (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Transport of the export-competent mRNP complex through the NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
mRNP complex dissociates from cytosolic face of NPC (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Elongation (Homo sapiens)
Peptide chain elongation (Homo sapiens)
Aminoacyl-tRNA binds to the ribosome at the A-site (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Hydrolysis of eEF1A:GTP (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
80S:aminoacyl tRNA:mRNA:eEF1A:GTP [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Peptide transfer from P-site tRNA to the A-site tRNA (Homo sapiens)
80S:Met-tRNAi:mRNA:aminoacyl-tRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Translocation of ribosome by 3 bases in the 3' direction (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
mRNP [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
eIF4F binds to mRNP (Homo sapiens)
eIF4F:mRNP [cytosol] (Homo sapiens)
mRNP [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
mRNP [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
The 60S subunit joins the translation initiation complex (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
eIF5B:GTP is hydrolyzed and released (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Eukaryotic Translation Termination (Homo sapiens)
GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GTP:80S Ribosome:mRNA:peptidyl-tRNA [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:peptidyl-tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
cleaved polypeptide:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:cleaved polypeptide [endoplasmic reticulum membrane] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
polypeptide+signal:Translocon [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
The SRP receptor binds the SRP:nascent peptide:ribosome complex (Homo sapiens)
SRP receptor:SRP:ribosome:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
SRP:polypeptide+signal:ribosome [cytosol] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
mRNA [cytosol] (Homo sapiens)
Participates
as a component of
Me-Q185-ETF1 dimer:eRF3:GDP:80S Ribosome:mRNA:tRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
80S Ribosome:mRNA:peptidyl-tRNA with elongating peptide [cytosol] (Homo sapiens)
Elongation complex with growing peptide chain [cytosol] (Homo sapiens)
membrane-bound ribosome:mRNA:cleaved polypeptide [endoplasmic reticulum membrane] (Homo sapiens)
membrane-bound ribosome:mRNA:polypeptide+signal [endoplasmic reticulum membrane] (Homo sapiens)
ribosome:mRNA:polypeptide+signal [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA:eIF5B:GTP [cytosol] (Homo sapiens)
40S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNP [cytosol] (Homo sapiens)
ISGylated 4EHP:mRNA [cytosol] (Homo sapiens)
eIF4F:mRNA [cytosol] (Homo sapiens)
mRNA:CBC:EJC:POLDIP3 [cytosol] (Homo sapiens)
NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Homo sapiens)
80S:Met-tRNAi:mRNA [cytosol] (Homo sapiens)
as an input of
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
Inferred To
Ghost homologue of mRNA [cytosol]
(Bos taurus)
Ghost homologue of mRNA [cytosol]
(Caenorhabditis elegans)
Ghost homologue of mRNA [cytosol]
(Canis familiaris)
Ghost homologue of mRNA [cytosol]
(Danio rerio)
Ghost homologue of mRNA [cytosol]
(Dictyostelium discoideum)
Ghost homologue of mRNA [cytosol]
(Drosophila melanogaster)
Ghost homologue of mRNA [cytosol]
(Gallus gallus)
Ghost homologue of mRNA [cytosol]
(Mus musculus)
Ghost homologue of mRNA [cytosol]
(Plasmodium falciparum)
Ghost homologue of mRNA [cytosol]
(Rattus norvegicus)
Ghost homologue of mRNA [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of mRNA [cytosol]
(Schizosaccharomyces pombe)
Ghost homologue of mRNA [cytosol]
(Sus scrofa)
Ghost homologue of mRNA [cytosol]
(Xenopus tropicalis)
Cross References
ChEBI
33699
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