mRNA Splicing - Minor Pathway

Stable Identifier
R-HSA-72165
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
U12 Dependent Splicing
ReviewStatus
5/5
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mRNA Splicing - Minor Pathway
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The splicing of a subset of pre-mRNA introns occurs by a second pathway, designated the AT-AC or U12-dependent splicing pathway. AT-AC introns have highly conserved, non-canonical splice sites that are removed by the AT-AC spliceosome, which contains distinct snRNAs (U11, U12, U4atac, U6atac) that are structurally and functionally analogous to the major spliceosome. U5 snRNA as well as many of the protein factors appear to be conserved between the two spliceosomes.
Literature References
PubMed ID Title Journal Year
10207048 AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.

Krainer, AR, Wu, Q

Mol Cell Biol 1999
9149533 Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge.

Steitz, JA, Tarn, WY

Trends Biochem Sci 1997
Participants
Events
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Event Information
Go Biological Process
mRNA splicing, via spliceosome (0000398)
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mRNA Splicing - Minor Pathway (Gallus gallus)
mRNA Splicing - Minor Pathway (Mus musculus)
mRNA Splicing - Minor Pathway (Rattus norvegicus)
mRNA Splicing - Minor Pathway (Sus scrofa)
mRNA Splicing - Minor Pathway (Xenopus tropicalis)
Created
Hastings, ML  (2003-08-22)
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