Cleavage at the 3'-Splice Site and Exon Ligation

Stable Identifier
Reaction [omitted]
Homo sapiens
Second step of mRNA splicing
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The second step of the splicing reaction results in cleavage of the transcript at the 3'splice site, and results in ligation of the two exons and excision of the intron.

Literature References
PubMed ID Title Journal Year
15024032 In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160

Ivshina, M, Nickerson, JA, Wagner, S, Chiosea, S

J. Cell Biol. 2004
15166247 Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module

Séraphin, B, Degot, S, Wendling, C, Stoll, I, Le Hir, H, Rio, MC, Alpy, F, Kedinger, V, Tomasetto, C

J. Biol. Chem. 2004
19103666 Isolation and characterization of post-splicing lariat-intron complexes

Ohno, M, Yoshimoto, R, Okawa, K, Kataoka, N

Nucleic Acids Res. 2009
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Jurica, MS, Burlingame, AL

RNA 2013
22419818 Perispeckles are major assembly sites for the exon junction core complex

Spiegelhalter, C, Schmidt, U, Degot, S, Kessler, P, Wendling, C, Daguenet, E, Le Hir, H, Rio, MC, Bertrand, E, Alpy, F, Baguet, A, Tomasetto, C

Mol. Biol. Cell 2012
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