Formation of the active Spliceosomal C (B*) complex

Stable Identifier
Reaction [transition]
Homo sapiens
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The active C complex is formed due to a conformational change in the intermediate C complex. After formation of the active C complex, the splicing reactions occur very rapidly.

Literature References
PubMed ID Title Journal Year
23345524 Rearrangements within human spliceosomes captured after exon ligation

Ilagan, JO, Chalkley, RJ, Jurica, MS, Burlingame, AL

RNA 2013
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

Grigorieff, N, Moore, MJ, Licklider, LJ, Gygi, SR, Jurica, MS

RNA 2002
12176931 Large-scale proteomic analysis of the human spliceosome.

Lamond, AI, Mann, M, Rappsilber, J, Ryder, U

Genome Res 2002
20423332 Contribution of DEAH-box protein DHX16 in human pre-mRNA splicing

Gencheva, M, Kato, M, Newo, AN, Lin, RJ

Biochem. J. 2010
Catalyst Activity

ATP hydrolysis activity of Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]

Orthologous Events
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