Formation of pre-mRNPs

Stable Identifier
R-HSA-72103
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

After the nascent pre-mRNA undergoes the initial capping and methylation reactions, it gets associated with numerous factors, including the various heterogeneous nuclear ribonucleoproteins (hnRNPS), the nuclear Cap-Binding Complex, and many splicing factors that make the pre-mRNA a substrate for splicing, 3'-end processing, and in some cases editing.

Literature References
PubMed ID Title Journal Year
8352591 hnRNP proteins and the biogenesis of mRNA

Dreyfuss, G, Matunis, MJ, Piņol-Roma, S, Burd, CG

Annu. Rev. Biochem. 1993
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Orthologous Events
Formation of pre-mRNPs (Drosophila melanogaster)
Formation of pre-mRNPs (Xenopus tropicalis)