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METTL3 [nucleoplasm]
Stable Identifier
R-HSA-72091
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MT-A70, N6-adenosine-methyltransferase 70 kDa subunit , Methyltransferase-like protein 3
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Internal Methylation of mRNA (Homo sapiens)
mRNA (N6-adenosine)-methyltransferase [nucleoplasm] (Homo sapiens)
METTL3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86U44 METTL3
Gene Names
METTL3, MTA70
Chain
initiator methionine:, chain:2-580
Reference Genes
BioGPS Gene:56339 METTL3
COSMIC (genes):METTL3 METTL3
CTD Gene:56339 METTL3
dbSNP Gene:56339 METTL3
ENSEMBL:ENSG00000165819 METTL3
HGNC:17563 METTL3
Monarch:56339 METTL3
NCBI Gene:56339 METTL3
OMIM:612472 METTL3
UCSC:Q86U44 METTL3
Reference Transcript
RefSeq:NM_019852.4 METTL3
Other Identifiers
11717975_a_at
11717976_x_at
11746193_a_at
11746194_x_at
11748568_a_at
11760613_at
16790381
209265_PM_s_at
209265_s_at
213653_PM_at
213653_at
242111_PM_at
242111_at
32245_at
32246_g_at
3556419
3556420
3556421
3556422
3556423
3556424
3556425
3556426
3556427
3556428
3556429
3556432
3556433
3556434
3556435
3556436
3556437
3556438
3556439
3556440
3556441
3556442
3556443
3556444
3556445
3556446
3556447
3556448
3556449
3556450
3556451
3556452
3556453
56339
7977749
82746_r_at
A_23_P351556
A_23_P54064
A_33_P3449397
GE82484
GO:0000398
GO:0001510
GO:0001734
GO:0002376
GO:0003723
GO:0003729
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0006325
GO:0006397
GO:0006974
GO:0007283
GO:0007623
GO:0008168
GO:0008173
GO:0008757
GO:0009048
GO:0016071
GO:0016556
GO:0016604
GO:0016607
GO:0016740
GO:0019827
GO:0021861
GO:0022414
GO:0030154
GO:0031053
GO:0032259
GO:0034644
GO:0036396
GO:0042063
GO:0043226
GO:0045087
GO:0045580
GO:0045727
GO:0045746
GO:0046982
GO:0048477
GO:0048511
GO:0048856
GO:0051445
GO:0060339
GO:0061157
GO:0098508
GO:0098542
GO:0140098
GO:0140640
GO:1902036
GO:1903679
GO:1904047
GO:1990204
HMNXSV003009934
Hs.168799.0.A1_3p_at
Hs.268149.1.A1_3p_a_at
Hs.268149.1.A1_3p_x_at
ILMN_1655635
PH_hs_0022798
TC14000922.hg
g12804482_3p_a_at
Participates
as a component of
mRNA (N6-adenosine)-methyltransferase [nucleoplasm] (Homo sapiens)
Inferred To
mettl3 [nucleoplasm]
(Xenopus tropicalis)
METTL3 [nucleoplasm]
(Bos taurus)
METTL3 [nucleoplasm]
(Canis familiaris)
METTL3 [nucleoplasm]
(Drosophila melanogaster)
METTL3 [nucleoplasm]
(Gallus gallus)
METTL3 [nucleoplasm]
(Mus musculus)
METTL3 [nucleoplasm]
(Plasmodium falciparum)
METTL3 [nucleoplasm]
(Sus scrofa)
Mettl3 [nucleoplasm]
(Rattus norvegicus)
Cross References
Guide to Pharmacology - Targets
3181
OpenTargets
ENSG00000165819
ENSEMBL
ENST00000298717
,
ENSP00000298717
HPA
ENSG00000165819-METTL3
PRO
Q86U44
Pharos - Targets
Q86U44
GlyGen
Q86U44
HMDB Protein
HMDBP00429
PDB
7O08
,
5K7U
,
7NHJ
,
8PWA
,
5TEY
,
8PWB
,
7O2X
,
7OEM
,
6TU1
,
7NID
,
5L6E
,
7ACD
,
7NI8
,
7NI7
,
7O2F
,
7NIA
,
8PW9
,
7OEK
,
7OEI
,
7OED
,
7O0L
,
7OEF
,
7OQL
,
5IL2
,
6TTX
,
7OEH
,
7O0P
,
7RX7
,
7O29
,
7O0R
,
6Y4G
,
8BN8
,
7NHG
,
7NHI
,
5K7M
,
6TTT
,
6TTP
,
7O2H
,
5L6D
,
7O2E
,
7NI9
,
7NHV
,
7O2I
,
7OEL
,
7OEJ
,
8PW8
,
7OQP
,
7O0M
,
7OQO
,
7RX6
,
7O0Q
,
5YZ9
,
7RX8
,
7OEE
,
5IL0
,
6TTV
,
7OEG
,
6TTW
,
7O27
,
7O28
,
7O09
,
5IL1
,
7NHH
,
5K7W
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31689 DNAJA1
2
SOH-C149,C150-DNAJA1 [cytosol]
(R-HSA-9857072)
DNAJA1 [cytosol]
(R-HSA-3371544)
0.527
2
UniProt:Q08J23 NSUN2
1
NSUN2 [nucleoplasm]
(R-HSA-6782382)
0.527
2
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