Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SRSF1 [nucleoplasm]
Stable Identifier
R-HSA-72031
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SF2/ASF/SFRS1, Splicing factor, arginine/serine-rich 1 (pre-mRNA splicing factor SF2, P33 subunit) (Alternative splicing factor ASF-1), Splicing factor, arginine/serine-rich 1, pre-mRNA splicing factor SF2, P33 subunit, Alternative splicing factor ASF-1
Locations in the PathwayBrowser for interactor UniProt:P61326 MAGOH
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNA derived from an Intron-Containing Transcript (Homo sapiens)
Docking of the TAP:EJC Complex with the NPC (Homo sapiens)
SRSF1 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
SRSF1 [nucleoplasm] (Homo sapiens)
mRNA Splicing - Minor Pathway (Homo sapiens)
Formation of AT-AC A complex (Homo sapiens)
SRSF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07955 SRSF1
Gene Names
SRSF1, ASF, SF2, SF2P33, SFRS1, OK/SW-cl.3
Chain
initiator methionine:1, chain:2-248
Reference Genes
BioGPS Gene:6426 SRSF1
COSMIC (genes):SRSF1 SRSF1
CTD Gene:6426 SRSF1
dbSNP Gene:6426 SRSF1
ENSEMBL:ENSG00000136450 SRSF1
HGNC:10780 SRSF1
KEGG Gene (Homo sapiens):6426 SRSF1
Monarch:6426 SRSF1
NCBI Gene:6426 SRSF1
OMIM:600812 SRSF1
UCSC:Q07955 SRSF1
Reference Transcript
RefSeq:NM_001078166.1 SRSF1
RefSeq:NM_006924.4 SRSF1
Other Identifiers
0003610358
11727811_a_at
11727812_s_at
11727813_a_at
11743269_a_at
11747684_a_at
11758600_s_at
13073
16846993
1X4A
201741_3p_x_at
201741_x_at
201742_x_at
208863_s_at
211784_s_at
227164_at
2M7S
2M8D
2O3D
36098_at
36099_at
3764113
3764114
3764115
3764116
3764117
3764118
3764119
3764120
3764121
3764122
3764123
3764124
3764125
3764126
3764127
3764128
3764129
3764130
3764131
3764136
3764138
3764139
3764140
3764141
3BEG
46035_at
4C0O
53598_s_at
53602_r_at
60888_r_at
61301
6426
8016898
91177_s_at
A_23_P49517
A_23_P49521
A_24_P921933
AAA03476
AAA35564
AAA35565
AAH10264
AAH33785
AB062124
AK312781
BAB93456
BAG35644
BC010264
BC033785
CAB013073
CCDS11600
CCDS58580
CH471109
EAW94485
EAW94486
ENSG00000136450
ENSP00000258962
ENSP00000462215
ENSP00000463223
ENST00000258962
ENST00000258962.4
ENST00000581979
ENST00000581979.5
ENST00000582730
ENST00000582730.6
EntrezGene:6426
EntrezGene:SRSF1
g13544106_3p_s_at
g5902075_3p_s_at
GE58054
GE86679
GE88490
GO:0000380
GO:0000381
GO:0000395
GO:0000398
GO:0003674
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005681
GO:0005737
GO:0006376
GO:0006397
GO:0006405
GO:0006406
GO:0006810
GO:0006913
GO:0008150
GO:0008380
GO:0016607
GO:0019899
GO:0022607
GO:0022618
GO:0031124
GO:0032991
GO:0034641
GO:0035145
GO:0043226
GO:0044547
GO:0045292
GO:0051028
GO:0065003
GO:0071013
HGNC:10780
HPA061301
Hs.44949.0.A1_3p_at
Hs.73737.0.S2_3p_s_at
ILMN_1795341
IPR000504
IPR012677
IPR029538
IPR034520
IPR035979
J3KSW7
J3KTL2
J3QQV5
M69040
M72709
MIM:600812
NM_001078166
NM_006924
NP_001071634
NP_008855
NR_034041
PF00076
PH_hs_0022174
SM00360
SRSF1
SRSF1-201
SRSF1-204
SRSF1-205
TC17001724.hg
TC17002724.hg
UPI0000001220
UPI000017A383
XR_429911
Participant Of
hasComponent
3' end cleaved, ligated exon containing complex [nucleoplasm]
ATAC A Complex [nucleoplasm]
ATAC C Complex [nucleoplasm]
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm]
capped mRNA:CBC:EJC:TREX (minus DDX39B) [nucleoplasm]
polyadenylated, capped mRNA:CBC:EJC:TREX:SRSF proteins [nucleoplasm]
post exon ligation complex [nucleoplasm]
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm]
Spliced mRNA:CBC:EJC:TREX [nucleoplasm]
Spliced mRNP [nucleoplasm]
Spliceosomal A Complex [nucleoplasm]
Spliceosomal Active C (B*) Complex [nucleoplasm]
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm]
Spliceosomal B Complex [nucleoplasm]
Spliceosomal E Complex [nucleoplasm]
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm]
input
Formation of AT-AC A complex
Formation of the Spliceosomal E complex
output
Docking of the TAP:EJC Complex with the NPC
Inferred To
SRSF1 [nucleoplasm] (Bos taurus)
SRSF1 [nucleoplasm] (Caenorhabditis elegans)
SRSF1 [nucleoplasm] (Canis familiaris)
SRSF1 [nucleoplasm] (Danio rerio)
SRSF1 [nucleoplasm] (Drosophila melanogaster)
SRSF1 [nucleoplasm] (Gallus gallus)
SRSF1 [nucleoplasm] (Mus musculus)
SRSF1 [nucleoplasm] (Plasmodium falciparum)
SRSF1 [nucleoplasm] (Rattus norvegicus)
SRSF1 [nucleoplasm] (Schizosaccharomyces pombe)
SRSF1 [nucleoplasm] (Sus scrofa)
SRSF1 [nucleoplasm] (Xenopus tropicalis)
Ghost homologue of SRSF1 [nucleoplasm] (Dictyostelium discoideum)
Cross References
RefSeq
NP_001071634.1
,
NP_008855.1
OpenTargets
ENSG00000136450
GeneCards
Q07955
PRO
Q07955
PDB
3BEG
,
2M8D
,
4C0O
,
1X4A
,
2O3D
,
2M7S
Interactors (61)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UBU9 NXF1
2
NXF1 [nucleoplasm]
(R-HSA-111690)
NXF1 [cytosol]
(R-HSA-156481)
0.76
5
UniProt:Q96SB4 SRPK1
0.667
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.662
7
UniProt:Q14684 RRP1B
0.649
6
UniProt:Q01081 U2AF1
1
U2AF1 [nucleoplasm]
(R-HSA-71985)
0.646
4
UniProt:O70551 SRPK1
0.639
5
IntAct:EBI-17172839 LNCRN
0.602
7
UniProt:P23511 NFYA
1
NFYA [nucleoplasm]
(R-HSA-420841)
0.599
5
UniProt:Q15287 RNPS1
2
RNPS1 [nucleoplasm]
(R-HSA-156778)
RNPS1 [cytosol]
(R-HSA-159256)
0.573
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.564
2
UniProt:P08621 SNRNP70
1
SNRNP70 [nucleoplasm]
(R-HSA-71913)
0.524
3
UniProt:O54781 SRPK2
0.524
3
UniProt:P51858 HDGF
1
HDGF [nucleoplasm]
(R-HSA-535593)
0.512
4
UniProt:Q86X95 CIR1
0.508
3
UniProt:P03211 EBNA1
0.508
2
UniProt:O00463 TRAF5
0.499
2
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.488
2
UniProt:P62995 TRA2B
1
TRA2B [nucleoplasm]
(R-HSA-8850859)
0.488
2
UniProt:P06921 VE2
0.488
2
UniProt:P49759-3 CLK1
0.488
2
IntAct:EBI-20986914 MRNA
0.462
2
IntAct:EBI-16421993 MRNA
0.462
2
IntAct:EBI-20986916 MRNA
0.462
2
IntAct:EBI-21196637 MRNA
0.462
2
IntAct:EBI-21003641 MRNA
0.462
2
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
IntAct:EBI-21196643 MRNA
0.462
2
IntAct:EBI-20978533 MRNA
0.462
2
IntAct:EBI-21196681 MRNA
0.462
2
IntAct:EBI-20986867 MRNA
0.462
2
IntAct:EBI-21196806 MRNA
0.462
2
UniProt:P11387 TOP1
2
SUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.462
3
UniProt:P61326 MAGOH
1
MAGOH [nucleoplasm]
(R-HSA-156658)
0.462
2
IntAct:EBI-21196689 MRNA
0.462
2
IntAct:EBI-20987118 MRNA
0.462
2
IntAct:EBI-20987111 MRNA
0.462
2
IntAct:EBI-21196652 MRNA
0.462
2
IntAct:EBI-20978528 MRNA
0.462
2
IntAct:EBI-21196816 MRNA
0.462
2
IntAct:EBI-20978553 MRNA
0.462
2
IntAct:EBI-20986938 MRNA
0.462
2
IntAct:EBI-20987101 MRNA
0.462
2
IntAct:EBI-21003667 MRNA
0.462
2
IntAct:EBI-21196665 MRNA
0.462
2
UniProt:P51957-2 NEK4
0.462
2
IntAct:EBI-21196622 MRNA
0.462
2
IntAct:EBI-20986925 MRNA
0.462
2
IntAct:EBI-21196628 MRNA
0.462
2
IntAct:EBI-21196823 MRNA
0.462
2
IntAct:EBI-21003674 MRNA
0.462
2
IntAct:EBI-20986929 MRNA
0.462
2
IntAct:EBI-16419307 MRA
0.462
2
IntAct:EBI-20986882 MRNA
0.462
2
IntAct:EBI-21003634 MRNA
0.462
2
IntAct:EBI-21196829 MRNA
0.462
2
IntAct:EBI-16412875 MRNA
0.462
2
IntAct:EBI-20986921 MRNA
0.462
2
IntAct:EBI-21196797 MRNA
0.462
2
IntAct:EBI-21196675 MRNA
0.462
2
IntAct:EBI-21196671 MRNA
0.462
2
IntAct:EBI-21196673 MRNA
0.462
2
© 2019
Reactome