Reactome | CPSF6-1 [nucleoplasm]

CPSF6-1 [nucleoplasm]

Stable Identifier

R-HSA-72013

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CF I - 68 kDa subunit, Cleavage Factor I 68 kDa subunit, CFIM68, Cleavage and polyadenylation specificity factor subunit 6, Cleavage factor Im complex 68 kDa subunit

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20562214	Arginine methylation in subunits of mammalian pre-mRNA cleavage factor I Martin, G, Chari, A, Keller, W, Dettwiler, S, Neuenkirchen, N, Blank, D, Ostareck-Lederer, A, Rüegsegger, U, Fischer, U	RNA	2010

External Reference Information

External Reference

UniProt:Q16630-1 CPSF6

Gene Names

CPSF6, CFIM68

Participates

as a component of

CF I [nucleoplasm] (Homo sapiens)

Inferred To

Ghost homologue of CPSF6-1 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of CPSF6-1 [nucleoplasm] (Xenopus tropicalis)

cfim-2 [nucleoplasm] (Caenorhabditis elegans)

CPSF6 [nucleoplasm] (Bos taurus)

CPSF6 [nucleoplasm] (Canis familiaris)

CPSF6 [nucleoplasm] (Gallus gallus)

CPSF6 [nucleoplasm] (Sus scrofa)

cpsf6 [nucleoplasm] (Danio rerio)

Cpsf6 [nucleoplasm] (Drosophila melanogaster)

Cpsf6 [nucleoplasm] (Mus musculus)

Cpsf6 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001287876.1, NP_008938.2

ENSEMBL

ENST00000435070, ENSG00000111605, ENSP00000391774, ENST00000266679, ENSP00000266679

OpenTargets

ENSG00000111605

GeneCards

CPSF6

HPA

ENSG00000111605-CPSF6

PRO

Q16630

Pharos - Targets

Q16630

GlyGen

Q16630

PDB

4B4N, 6GX9, 4U0B, 3P6Y, 3Q2T, 8CL1, 3P5T, 4U0A, 8GDV, 4WYM, 8EJL, 7SNQ, 6AY9, 7ZUD, 3Q2S

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0M0 WWP1	1	WWP1 [cytosol] (R-HSA-976037)	0.783	6
UniProt:Q9Y3C6 PPIL1	1	PPIL1 [nucleoplasm] (R-HSA-8867892)	0.666	4
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.659	4
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.527	2
UniProt:Q6NYC1 JMJD6	1	JMJD6 [nucleoplasm] (R-HSA-4754226)	0.527	3
UniProt:O60828 PQBP1	1	PQBP1 [nucleoplasm] (R-HSA-8867889)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.483	2
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.483	2
UniProt:Q14966 ZNF638	1	ZNF638 [nucleoplasm] (R-HSA-8939429)	0.483	2
UniProt:O14776 TCERG1	1	TCERG1 [nucleoplasm] (R-HSA-3246027)	0.483	2
UniProt:Q15424 SAFB	3	SAFB [nucleoplasm] (R-HSA-4085379) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343)	0.483	2
UniProt:Q9BYW2 SETD2	1	SETD2 [nucleoplasm] (R-HSA-1183220)	0.483	2
UniProt:Q8IX12 CCAR1	1	CCAR1 [nucleoplasm] (R-HSA-72048)	0.483	2
UniProt:Q5VT52 RPRD2	1	RPRD2 [nucleoplasm] (R-HSA-6814906)	0.483	2
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2
UniProt:O75152 ZC3H11A	1	ZC3H11A [nucleoplasm] (R-HSA-8850659)	0.483	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.483	2
UniProt:Q96MU7 YTHDC1	1	YTHDC1 [nucleoplasm] (R-HSA-9935812)	0.483	2
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.483	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.483	2
UniProt:Q9UPT8 ZC3H4	1	ZC3H4 [nucleoplasm] (R-HSA-9930063)	0.483	2
UniProt:Q5T8P6 RBM26	1	RBM26 [nucleoplasm] (R-HSA-9935784)	0.483	2
UniProt:Q07666 KHDRBS1	3	KHDRBS1 [nucleoplasm] (R-HSA-8848941) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995)	0.483	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.483	2

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