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PAPOLA [nucleoplasm]
Stable Identifier
R-HSA-71997
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Poly(A) polymerase alpha, PAP_HUMAN, Poly(A) polymerase alpha , PAP, Polynucleotide adenylyltransferase alpha
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51003 PAPOLA
Gene Names
PAPOLA, PAP
Chain
initiator methionine:, chain:2-745
Reference Genes
BioGPS Gene:10914 PAPOLA
COSMIC (genes):PAPOLA PAPOLA
CTD Gene:10914 PAPOLA
dbSNP Gene:10914 PAPOLA
ENSEMBL:ENSG00000090060 PAPOLA
ENSEMBL_homo_sapiens_GENE:ENSG00000090060.19 PAPOLA
HGNC:14981 PAPOLA
KEGG Gene (Homo sapiens):10914 PAPOLA
Monarch:10914 PAPOLA
NCBI Gene:10914 PAPOLA
OMIM:605553 PAPOLA
UCSC:P51003 PAPOLA
Reference Transcript
RefSeq:NM_032632.4 PAPOLA
RefSeq:NM_001293628.1 PAPOLA
RefSeq:NM_001252007.1 PAPOLA
RefSeq:NM_001293632.1 PAPOLA
RefSeq:NM_001293627.1 PAPOLA
RefSeq:NM_001252006.1 PAPOLA
Other Identifiers
10914
11719008_a_at
11719009_a_at
11744391_a_at
11744392_a_at
11744393_x_at
11745871_a_at
11745872_a_at
11745873_x_at
11748732_x_at
11759554_at
209388_PM_at
209388_at
212718_PM_at
212718_at
212720_PM_at
212720_at
222035_PM_s_at
222035_s_at
228569_PM_at
228569_at
34855_at
3550394
3550396
3550398
3550400
3550402
3550404
3550406
3550409
3550411
3550412
3550413
3550414
3550415
3550416
3550417
3550418
3550419
3550420
3550421
3550422
3550425
3550428
3550429
3550432
3550433
3550438
3550439
3550440
3550441
3550444
3550446
3550450
3550451
3550452
3550453
3550454
3550455
3550456
3550457
44969_at
45351_g_at
49247_at
51720_r_at
7976598
A_14_P106857
A_23_P376239
A_23_P419051
A_23_P99559
A_24_P141995
GO:0000166
GO:0000287
GO:0003723
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0006378
GO:0006397
GO:0016071
GO:0016740
GO:0016779
GO:0030145
GO:0031123
GO:0031124
GO:0031440
GO:0043226
GO:0043631
GO:0046872
GO:0180011
GO:1990817
HMNXSV003022004
HMNXSV003027104
Hs.49007.1.S1_3p_a_at
Hs.49007.2.S1_3p_at
Hs.5324.2.A1_3p_at
Hs.5324.2.A2_3p_at
ILMN_1798354
PH_hs_0022981
TC14000605.hg
X76770_at
g12654216_3p_at
g12654216_3p_x_at
Participates
as an input of
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
as a component of
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
as an output of
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
Inferred To
hrg [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of PAPOLA [nucleoplasm]
(Danio rerio)
PAPOLA [nucleoplasm]
(Bos taurus)
PAPOLA [nucleoplasm]
(Caenorhabditis elegans)
PAPOLA [nucleoplasm]
(Canis familiaris)
PAPOLA [nucleoplasm]
(Dictyostelium discoideum)
PAPOLA [nucleoplasm]
(Gallus gallus)
PAPOLA [nucleoplasm]
(Mus musculus)
PAPOLA [nucleoplasm]
(Rattus norvegicus)
PAPOLA [nucleoplasm]
(Sus scrofa)
PAPOLA [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001238936.1
,
NP_001280557.1
,
NP_001280556.1
,
NP_001238935.1
,
NP_001280561.1
,
NP_116021.2
OpenTargets
ENSG00000090060
GeneCards
P51003
HPA
ENSG00000090060-PAPOLA
Ensembl
ENSG00000090060
,
ENST00000557320
,
ENSP00000450437
,
ENST00000216277
,
ENSP00000216277
PRO
P51003
Pharos - Targets
P51003
HMDB Protein
HMDBP01078
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62259 Ywhae
1
14-3-3 epsilon [cytosol]
(R-MMU-1445119)
0.593
3
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