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PAPOLA [nucleoplasm]
Stable Identifier
R-HSA-71997
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Poly(A) polymerase alpha, PAP_HUMAN, Poly(A) polymerase alpha , PAP, Polynucleotide adenylyltransferase alpha
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Polymerase II Transcription Termination (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
Cleavage of mRNA at the 3'-end (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
TREX complex binds spliced, capped mRNA:CBC:EJC cotranscriptionally (Homo sapiens)
Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
mRNA polyadenylation (Homo sapiens)
3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Cleavage at the 3'-Splice Site and Exon Ligation (Homo sapiens)
Spliced mRNP [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Formation of Exon Junction Complex (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
pre-EJC:Spliceosomal C:pre-mRNP:CBC [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Formation of an intermediate Spliceosomal C (Bact) complex (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Formation of the Cleavage and Polyadenylation Complex (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Formation of the active Spliceosomal C (B*) complex (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C (Bact) Complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Lariat Formation and 5'-Splice Site Cleavage (Homo sapiens)
Spliceosomal Active C (B*) Complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Spliceosomal active C complex with lariat containing, 5'-end cleaved pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Processing of Capped Intronless Pre-mRNA (Homo sapiens)
Processing of Intronless Pre-mRNAs (Homo sapiens)
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Cleavage and polyadenylation of Intronless Pre-mRNA (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
PAPOLA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51003 PAPOLA
Gene Names
PAPOLA, PAP
Chain
initiator methionine:1, chain:2-745
Reference Genes
BioGPS Gene:10914 PAPOLA
COSMIC (genes):PAPOLA PAPOLA
CTD Gene:10914 PAPOLA
dbSNP Gene:10914 PAPOLA
ENSEMBL:ENSG00000090060 PAPOLA
HGNC:14981 PAPOLA
KEGG Gene (Homo sapiens):10914 PAPOLA
Monarch:10914 PAPOLA
NCBI Gene:10914 PAPOLA
OMIM:605553 PAPOLA
UCSC:P51003 PAPOLA
Reference Transcript
RefSeq:NM_001293627.1 PAPOLA
RefSeq:NM_001293632.1 PAPOLA
RefSeq:NM_001293628.1 PAPOLA
RefSeq:NM_001252007.1 PAPOLA
RefSeq:NM_001252006.1 PAPOLA
RefSeq:NM_032632.4 PAPOLA
Other Identifiers
0006380044
10914
11719008_a_at
11719009_a_at
11744391_a_at
11744392_a_at
11744393_x_at
11745871_a_at
11745872_a_at
11745873_x_at
11748732_x_at
11759554_at
209388_at
212718_at
212720_at
222035_s_at
228569_at
34855_at
3550394
3550396
3550398
3550400
3550402
3550404
3550406
3550409
3550411
3550412
3550413
3550414
3550415
3550416
3550417
3550418
3550419
3550420
3550421
3550422
3550425
3550428
3550429
3550432
3550433
3550438
3550439
3550440
3550441
3550444
3550446
3550450
3550451
3550452
3550453
3550454
3550455
3550456
3550457
44969_at
45351_g_at
49247_at
51720_r_at
7976598
A_14_P106857
A_23_P376239
A_23_P419051
A_23_P99559
A_24_P141995
GO:0000166
GO:0000287
GO:0000398
GO:0003674
GO:0003723
GO:0004652
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006369
GO:0006378
GO:0006397
GO:0008150
GO:0009058
GO:0016740
GO:0016779
GO:0030145
GO:0031123
GO:0031124
GO:0031440
GO:0034641
GO:0043167
GO:0043226
GO:0043631
GO:0046872
Hs.49007.1.S1_3p_a_at
Hs.49007.2.S1_3p_at
Hs.5324.2.A1_3p_at
Hs.5324.2.A2_3p_at
ILMN_1798354
PH_hs_0022981
TC14000605.hg
X76770_at
g12654216_3p_at
g12654216_3p_x_at
Participant Of
output
Cleavage and polyadenylation of Intronless Pre-mRNA
mRNA polyadenylation
input
Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex
Formation of the Cleavage and Polyadenylation Complex
hasComponent
3' end cleaved, ligated exon containing complex [nucleoplasm]
Cleavage and Polyadenylation Complex [nucleoplasm]
intronless pre-mRNA cleavage complex [nucleoplasm]
upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm]
Inferred To
papola [nucleoplasm] (Danio rerio)
Papola [nucleoplasm] (Mus musculus)
Papola [nucleoplasm] (Rattus norvegicus)
Ghost homologue of PAPOLA [nucleoplasm] (Drosophila melanogaster)
PAP1 [nucleoplasm] (Saccharomyces cerevisiae)
PAPOLA [nucleoplasm] (Canis familiaris)
PAPOLA [nucleoplasm] (Gallus gallus)
PAPOLA [nucleoplasm] (Sus scrofa)
PAPOLA [nucleoplasm] (Xenopus tropicalis)
papA [nucleoplasm] (Dictyostelium discoideum)
pla1 [nucleoplasm] (Schizosaccharomyces pombe)
pap-1 [nucleoplasm] (Caenorhabditis elegans)
Cross References
RefSeq
NP_001238935.1
,
NP_001280561.1
,
NP_001238936.1
,
NP_116021.2
,
NP_001280556.1
,
NP_001280557.1
OpenTargets
ENSG00000090060
IntEnz
2.7.7.19
HPA
ENSG00000090060-PAPOLA
GeneCards
P51003
Ensembl
ENSP00000216277
,
ENSG00000090060
,
ENSP00000450437
,
ENST00000557320
,
ENST00000216277
PRO
P51003
HMDB Protein
HMDBP01078
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62259 Ywhae
1
14-3-3 epsilon [cytosol]
(R-MMU-1445119)
0.593
3
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