Reactome | CPSF3 [nucleoplasm]

CPSF3 [nucleoplasm]

Stable Identifier

R-HSA-71993

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CPSC_HUMAN, Cleavage and polyadenylation specificity factor, 73 kDa subunit, CPSF 73 kDa subunit, CPSF73

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF3 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF3 [nucleoplasm] (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF3 [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UKF6 CPSF3

Gene Names

CPSF3, CPSF73

Chain

initiator methionine:, chain:2-684

Reference Genes

BioGPS Gene:51692 CPSF3

COSMIC (genes):CPSF3 CPSF3

CTD Gene:51692 CPSF3

dbSNP Gene:51692 CPSF3

ENSEMBL:ENSG00000119203 CPSF3

HGNC:2326 CPSF3

KEGG:hsa:51692 CPSF3

Monarch:51692 CPSF3

NCBI Gene:51692 CPSF3

OMIM:606029 CPSF3

UCSC:Q9UKF6 CPSF3

Reference Transcript

RefSeq:NM_016207.3 CPSF3

Other Identifiers

11717571_a_at

16876881

225082_PM_at

225082_at

228227_at

2468919

2468921

2468922

2468923

2468924

2468926

2468927

2468928

2468930

2468931

2468932

2468933

2468935

2468936

2468937

2468938

2468939

2468940

2468941

2468942

2468944

2468946

2468947

2468950

2468951

2468952

2468954

2468955

51692

54643_at

8040142

A_14_P113018

A_23_P28688

GE58700

GO:0003723

GO:0003824

GO:0004519

GO:0004521

GO:0004534

GO:0005515

GO:0005634

GO:0005654

GO:0005847

GO:0006396

GO:0006397

GO:0006398

GO:0016071

GO:0016787

GO:0031124

GO:0043226

GO:0046872

GO:0140098

GO:0180010

GO:1900087

GO:1990904

HMNXSV003003870

Hs.16251.0.S1_3p_at

ILMN_2087528

PH_hs_0001502

TC02000047.hg

Participates

as a component of

CPSF [nucleoplasm] (Homo sapiens)

Inferred To

Cpsf3 [nucleoplasm] (Rattus norvegicus)

CPSF3 [nucleoplasm] (Bos taurus)

CPSF3 [nucleoplasm] (Canis familiaris)

CPSF3 [nucleoplasm] (Dictyostelium discoideum)

CPSF3 [nucleoplasm] (Drosophila melanogaster)

CPSF3 [nucleoplasm] (Gallus gallus)

CPSF3 [nucleoplasm] (Mus musculus)

CPSF3 [nucleoplasm] (Saccharomyces cerevisiae)

CPSF3 [nucleoplasm] (Schizosaccharomyces pombe)

CPSF3 [nucleoplasm] (Sus scrofa)

cpsf3 [nucleoplasm] (Danio rerio)

cpsf3 [nucleoplasm] (Xenopus tropicalis)

cpsf-3 [nucleoplasm] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000238112, ENSP00000238112, ENSG00000119203

OpenTargets

ENSG00000119203

GeneCards

CPSF3

HPA

ENSG00000119203-CPSF3

PRO

Q9UKF6

Pharos - Targets

Q9UKF6

GlyGen

Q9UKF6

PDB

6V4X, 8T1Q, 8T1R, 2I7T, 2I7V, 6M8Q

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95639 CPSF4	1	CPSF4 [nucleoplasm] (R-HSA-169104)	0.643	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3

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