Reactome | CPSF2 [nucleoplasm]

CPSF2 [nucleoplasm]

Stable Identifier

R-HSA-71991

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CPSB_HUMAN, Cleavage and polyadenylation specificity factor, 100 kDa subunit, CPSF 100 kDa subunit , CPSF100

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Dengue Virus Infection (Homo sapiens)
      - Dengue Virus-Host Interactions (Homo sapiens)
        
        NS5 interacts with Spliceosome (Homo sapiens)
        
        NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
        
        Cleavage and Polyadenylation Complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF2 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF2 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P2I0 CPSF2

Gene Names

CPSF2, CPSF100, KIAA1367

Chain

chain:1-782

Reference Genes

BioGPS Gene:53981 CPSF2

COSMIC - genes:CPSF2 CPSF2

CTD Gene:53981 CPSF2

dbSNP Gene:53981 CPSF2

ENSEMBL:ENSG00000165934 CPSF2

HGNC:2325 CPSF2

KEGG:hsa:53981 CPSF2

Monarch:53981 CPSF2

NCBI Gene:53981 CPSF2

OMIM:606028 CPSF2

UCSC:Q9P2I0 CPSF2

Reference Transcript

Other Identifiers

11730828_a_at

16787540

225986_3p_x_at

225986_PM_x_at

225986_x_at

225994_PM_at

225994_at

233208_3p_x_at

233208_PM_x_at

233208_x_at

3548790

3548791

3548792

3548793

3548794

3548795

3548797

3548798

3548799

3548800

3548801

3548802

3548803

3548805

3548806

3548807

3548808

3548810

3548811

3548812

3548813

3548814

3548815

3548816

3548817

3548819

3548820

3548821

3548822

3548823

3548824

3548825

3548826

3548827

3548828

3548829

3548830

53981

73177_at

7976243

A_14_P101212

A_23_P99837

A_24_P82074

GE61637

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005847

GO:0006397

GO:0006398

GO:0016020

GO:0016071

GO:0098794

GO:0098978

HMNXSV003031802

Hs.224961.0.S1_3p_at

Hs.224961.1.S1_3p_x_at

ILMN_1673185

ILMN_2144116

PH_hs_0028426

TC14000568.hg

Participates

as an input of

Formation of the CPSF complex (Homo sapiens)

as a component of

Inferred To

CPSF2 [nucleoplasm] (Bos taurus)

CPSF2 [nucleoplasm] (Canis familiaris)

CPSF2 [nucleoplasm] (Gallus gallus)

CPSF2 [nucleoplasm] (Sus scrofa)

cpsf2 [nucleoplasm] (Danio rerio)

cpsf2 [nucleoplasm] (Dictyostelium discoideum)

cpsf2 [nucleoplasm] (Xenopus tropicalis)

Cpsf100 [nucleoplasm] (Drosophila melanogaster)

cpsf-2 [nucleoplasm] (Caenorhabditis elegans)

cft2 [nucleoplasm] (Schizosaccharomyces pombe)

CFT2 [nucleoplasm] (Saccharomyces cerevisiae)

Cpsf2 [nucleoplasm] (Mus musculus)

Cpsf2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001309201.1, NP_059133.1

ENSEMBL

ENST00000298875, ENSP00000298875, ENSG00000165934

OpenTargets

ENSG00000165934

GeneCards

CPSF2

HPA

ENSG00000165934-CPSF2

PRO

Q9P2I0

Pharos - Targets

Q9P2I0

GlyGen

Q9P2I0

PDB

6URG, 6V4X

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92797 SYMPK	1	SYMPK [nucleoplasm] (R-HSA-4615988)	0.847	7
UniProt:Q9UKF6 CPSF3	2	Ub-K63-CPSF3 [nucleoplasm] (R-HSA-9970273) CPSF3 [nucleoplasm] (R-HSA-71993)	0.802	10
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.564	2
UniProt:Q9H6E5 TUT1	1	TUT1 [nucleoplasm] (R-HSA-9970846)	0.527	2
UniProt:Q6UN15 FIP1L1	9	FIP1L1 [nucleoplasm] (R-HSA-6805150) FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9672499) FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9672506) p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673872) p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9673621) p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9673879) p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] (R-HSA-9673867)	0.527	2
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	2
UniProt:P33240 CSTF2	1	CSTF2 [nucleoplasm] (R-HSA-72003)	0.499	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.499	4
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2

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