Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PFKFB4 [cytosol]
Stable Identifier
R-HSA-71798
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4, 6PF-2-K/Fru- 2,6-P2ASE testis-type isozyme, 6-phosphofructo-2-kinase , Fructose-2,6-bisphosphatase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
PFKFKB dimer phosphorylates Fru(6)P (Homo sapiens)
PFKFB dimers [cytosol] (Homo sapiens)
PFKFB4 dimer [cytosol] (Homo sapiens)
PFKFB4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16877 PFKFB4
Gene Names
PFKFB4
Chain
chain:1-469
Reference Genes
BioGPS Gene:5210 PFKFB4
COSMIC (genes):PFKFB4 PFKFB4
CTD Gene:5210 PFKFB4
dbSNP Gene:5210 PFKFB4
ENSEMBL:ENSG00000114268 PFKFB4
HGNC:8875 PFKFB4
KEGG:hsa:5210 PFKFB4
Monarch:5210 PFKFB4
NCBI Gene:5210 PFKFB4
OMIM:605320 PFKFB4
UCSC:Q16877 PFKFB4
Reference Transcript
RefSeq:NM_001317134.1 PFKFB4
RefSeq:NM_001317136.1 PFKFB4
RefSeq:NM_004567.3 PFKFB4
RefSeq:NM_001317138.1 PFKFB4
RefSeq:NM_001317137.1 PFKFB4
RefSeq:NM_001317135.1 PFKFB4
Other Identifiers
11722405_at
11722406_at
11730718_at
11747809_a_at
11753357_a_at
16953424
206246_PM_at
206246_at
228499_PM_at
228499_at
232674_PM_at
232674_at
2673309
2673311
2673313
2673314
2673315
2673317
2673318
2673319
2673321
2673324
2673325
2673326
2673327
2673329
2673330
2673331
2673332
2673333
2673335
2673336
2673337
2673341
2673342
2673343
2673344
2673502
2673504
31979_at
5210
59119_at
72555_at
8086961
A_24_P362904
A_33_P3279629
D49818_at
GE81409
GO:0000166
GO:0003824
GO:0003873
GO:0004331
GO:0005515
GO:0005524
GO:0005829
GO:0005975
GO:0006000
GO:0006003
GO:0016301
GO:0016740
GO:0016787
GO:0046835
GO:1901135
HMNXSV003005606
HMNXSV003026837
HMNXSV003029308
Hs.198278.1.A1_3p_at
Hs.314295.0.S1_3p_at
ILMN_1652413
ILMN_1653292
PH_hs_0011680
TC03003380.hg
g4758901_3p_at
Participates
as a component of
PFKFB4 dimer [cytosol] (Homo sapiens)
Inferred To
PFKFB4 [cytosol]
(Bos taurus)
PFKFB4 [cytosol]
(Caenorhabditis elegans)
PFKFB4 [cytosol]
(Canis familiaris)
PFKFB4 [cytosol]
(Danio rerio)
PFKFB4 [cytosol]
(Dictyostelium discoideum)
PFKFB4 [cytosol]
(Drosophila melanogaster)
PFKFB4 [cytosol]
(Gallus gallus)
PFKFB4 [cytosol]
(Mus musculus)
PFKFB4 [cytosol]
(Rattus norvegicus)
PFKFB4 [cytosol]
(Saccharomyces cerevisiae)
PFKFB4 [cytosol]
(Schizosaccharomyces pombe)
PFKFB4 [cytosol]
(Sus scrofa)
PFKFB4 [cytosol]
(Xenopus tropicalis)
Homologues of PFKFB4 [cytosol]
(Caenorhabditis elegans)
Homologues of PFKFB4 [cytosol]
(Dictyostelium discoideum)
Homologues of PFKFB4 [cytosol]
(Saccharomyces cerevisiae)
Homologues of PFKFB4 [cytosol]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENSP00000232375
,
ENSG00000114268
,
ENST00000383734
,
ENST00000232375
,
ENSP00000373240
OpenTargets
ENSG00000114268
GeneCards
PFKFB4
HPA
ENSG00000114268-PFKFB4
PRO
Q16877
Pharos - Targets
Q16877
HMDB Protein
HMDBP00798
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.643
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text