Reactome | PFKFB3 [cytosol]

PFKFB3 [cytosol]

Stable Identifier

R-HSA-71794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, 6PF-2-K/Fru- 2,6-P2ASE brain/placenta-type isozyme, iPFK-2, 6- phosphofructo-2-kinase , Fructose-2,6-bisphosphatase

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
  - Glucose metabolism (Homo sapiens)
    - Glycolysis (Homo sapiens)
      - Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
        
        PFKFKB dimer phosphorylates Fru(6)P (Homo sapiens)
        
        PFKFB dimers [cytosol] (Homo sapiens)
        
        PFKFB3 dimer [cytosol] (Homo sapiens)
        
        PFKFB3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16875 PFKFB3

Gene Names

PFKFB3

Chain

chain:1-520

Reference Genes

BioGPS Gene:5209 PFKFB3

COSMIC (genes):PFKFB3 PFKFB3

CTD Gene:5209 PFKFB3

dbSNP Gene:5209 PFKFB3

ENSEMBL:ENSG00000170525 PFKFB3

HGNC:8874 PFKFB3

KEGG:hsa:5209 PFKFB3

Monarch:5209 PFKFB3

NCBI Gene:5209 PFKFB3

OMIM:605319 PFKFB3

UCSC:Q16875 PFKFB3

Reference Transcript

Other Identifiers

11717732_s_at

11733141_s_at

11755611_a_at

11756035_x_at

16702175

202464_PM_s_at

202464_s_at

3233606

3233620

3233621

3233622

3233623

3233624

3233625

3233629

3233631

3233632

3233634

3233635

3233636

3233637

3233638

3233639

3233640

3233642

3233644

3233645

3233646

3233648

3233649

3233650

3233651

3233654

3233655

3233656

3233657

3233658

3233659

3233660

3233661

3233663

3233664

3233665

3233666

3233667

3233674

37110_at

37111_g_at

39522_at

5209

56246_at

7926037

84358_at

A_14_P107212

A_14_P201229

A_23_P95755

A_24_P111096

A_24_P206604

A_24_P261259

D49817_at

GE519521

GE61541

GO:0000166

GO:0003824

GO:0003873

GO:0004331

GO:0005515

GO:0005524

GO:0005654

GO:0005829

GO:0005975

GO:0006000

GO:0006003

GO:0016301

GO:0016740

GO:0016787

GO:0046835

GO:1901135

HMNXSV003032129

ILMN_1660847

ILMN_2186061

PH_hs_0009866

PH_hs_0032109

TC10000053.hg

TC10001860.hg

g4758899_3p_a_at

Participates

as a component of

PFKFB3 dimer [cytosol] (Homo sapiens)

Inferred To

PFKFB3 [cytosol] (Bos taurus)

PFKFB3 [cytosol] (Caenorhabditis elegans)

PFKFB3 [cytosol] (Canis familiaris)

PFKFB3 [cytosol] (Danio rerio)

PFKFB3 [cytosol] (Dictyostelium discoideum)

PFKFB3 [cytosol] (Drosophila melanogaster)

PFKFB3 [cytosol] (Gallus gallus)

PFKFB3 [cytosol] (Mus musculus)

PFKFB3 [cytosol] (Rattus norvegicus)

PFKFB3 [cytosol] (Saccharomyces cerevisiae)

PFKFB3 [cytosol] (Schizosaccharomyces pombe)

PFKFB3 [cytosol] (Sus scrofa)

Cross References

Guide to Pharmacology - Targets

2937

OpenTargets

ENSG00000170525

ENSEMBL

ENSG00000170525, ENSP00000369100, ENST00000360521, ENSP00000369115, ENSP00000353712, ENST00000379789, ENSP00000443319, ENST00000379775, ENST00000536985

HPA

ENSG00000170525-PFKFB3

GeneCards

PFKFB3

ZINC target

Q16875

PRO

Q16875

Pharos - Targets

Q16875

GlyGen

Q16875

HMDB Protein

HMDBP00796

PDB

6HVI, 5AJZ, 6ETJ, 2AXN, 3QPW, 6HVH, 5AJX, 3QPU, 5AJY, 3QPV, 6HVJ, 6IBX, 4D4M, 6IC0, 4D4L, 2DWO, 5AJV, 2DWP, 5AJW, 4D4J, 6IBZ, 6IBY, 4D4K, 4MA4, 5AK0, 2I1V

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.527	2