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PFKFB1 [cytosol]
Stable Identifier
R-HSA-71785
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1, 6PF-2-K/Fru- 2,6-P2ASE liver isozyme, 6-phosphofructo-2-kinase , Fructose-2,6-bisphosphatase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
PKA-mediated phosphorylation of key metabolic factors (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
PFKFB1 dimer [cytosol] (Homo sapiens)
PFKFB1 [cytosol] (Homo sapiens)
PP2A-mediated dephosphorylation of key metabolic factors (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
PFKFB1 dimer [cytosol] (Homo sapiens)
PFKFB1 [cytosol] (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Glycolysis (Homo sapiens)
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism (Homo sapiens)
D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP (Homo sapiens)
PFKFB dimers [cytosol] (Homo sapiens)
PFKFB1 dimer [cytosol] (Homo sapiens)
PFKFB1 [cytosol] (Homo sapiens)
Dephosphorylation of phosphoPFKFB1 by PP2A complex (Homo sapiens)
PFKFB1 dimer [cytosol] (Homo sapiens)
PFKFB1 [cytosol] (Homo sapiens)
Phosphorylation of PF2K-Pase by PKA catalytic subunit (Homo sapiens)
PFKFB1 dimer [cytosol] (Homo sapiens)
PFKFB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16118 PFKFB1
Gene Names
PFKFB1, F6PK, PFRX
Chain
initiator methionine:1, chain:2-471
Reference Genes
BioGPS Gene:5207 PFKFB1
COSMIC (genes):PFKFB1 PFKFB1
CTD Gene:5207 PFKFB1
dbSNP Gene:5207 PFKFB1
ENSEMBL:ENSG00000158571 PFKFB1
ENSEMBL:ENSG00000158571.11 PFKFB1
HGNC:8872 PFKFB1
KEGG Gene (Homo sapiens):5207 PFKFB1
Monarch:5207 PFKFB1
NCBI Gene:5207 PFKFB1
OMIM:311790 PFKFB1
UCSC:P16118 PFKFB1
Reference Transcript
RefSeq:NM_001271805.1 PFKFB1
RefSeq:NM_002625.3 PFKFB1
RefSeq:NM_001271804.1 PFKFB1
Other Identifiers
11750181_a_at
17111501
207537_PM_at
207537_at
33980_at
4009814
4009815
4009816
4009817
4009821
4009823
4009824
4009825
4009828
4009829
4009831
4009832
4009833
4009834
4009835
4009836
4009838
4009839
4009844
5207
8173120
A_24_P203106
GE59777
GO:0000166
GO:0003824
GO:0003873
GO:0004331
GO:0005515
GO:0005524
GO:0005829
GO:0005975
GO:0006000
GO:0006003
GO:0006091
GO:0006094
GO:0006096
GO:0008152
GO:0016301
GO:0016310
GO:0016740
GO:0016787
GO:0019900
GO:0031100
GO:0032868
GO:0033133
GO:0033762
GO:0042594
GO:0042802
GO:0043540
GO:0046835
GO:0048856
GO:0051384
GO:0051591
GO:0055086
GO:0070095
GO:1901135
GO:1904539
HMNXSV003017916
ILMN_1741600
PH_hs_0001257
PH_hs_0025955
TC0X001076.hg
X52638_at
g4505744_3p_at
Participates
as a component of
PFKFB1 dimer [cytosol] (Homo sapiens)
Other forms of this molecule
p-S33-PFKFB1 [cytosol]
Inferred To
pfkfb1 [cytosol]
(Xenopus tropicalis)
wu:fi11h10 [cytosol]
(Danio rerio)
PFKFB1 [cytosol]
(Bos taurus)
PFKFB1 [cytosol]
(Caenorhabditis elegans)
PFKFB1 [cytosol]
(Canis familiaris)
PFKFB1 [cytosol]
(Dictyostelium discoideum)
PFKFB1 [cytosol]
(Gallus gallus)
PFKFB1 [cytosol]
(Mus musculus)
PFKFB1 [cytosol]
(Rattus norvegicus)
PFKFB1 [cytosol]
(Saccharomyces cerevisiae)
PFKFB1 [cytosol]
(Schizosaccharomyces pombe)
PFKFB1 [cytosol]
(Sus scrofa)
Pfrx [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001258733.1
,
NP_002616.2
,
NP_001258734.1
OpenTargets
ENSG00000158571
GeneCards
P16118
HPA
ENSG00000158571-PFKFB1
ZINC target
P16118
Ensembl
ENSP00000364145
,
ENSP00000444074
,
ENST00000375006
,
ENST00000545676
,
ENSG00000158571
PRO
P16118
Pharos - Targets
P16118
HMDB Protein
HMDBP00799
PDB
1K6M
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35557 GCK
8
GCK A378T [cytosol]
(R-HSA-5621850)
GCK G261R [cytosol]
(R-HSA-5621848)
GCK E339K [cytosol]
(R-HSA-5621913)
GCK E279* [cytosol]
(R-HSA-5621903)
GCK T228M [cytosol]
(R-HSA-5621852)
GCK G229R [cytosol]
(R-HSA-5621863)
GCK [nucleoplasm]
(R-HSA-450102)
GCK [cytosol]
(R-HSA-450094)
0.558
2
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