Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+

Stable Identifier
R-HSA-71783
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
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Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+
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Mitochondrial malate dehydrogenase catalyzes the reversible reaction of oxaloacetate and NADH + H+ to form malate and NAD+ (Luo et al. 2006). Unpublished crystallographic data indicate that the protein is a dimer (PDB 3E04).

Literature References
PubMed ID Title Journal Year
16740313 An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates

Liu, J, Wang, X, Long, J, Luo, C

J Biochem Biophys Methods 2006
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Catalyst Activity

L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix]

Physical Entity
MDH2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
L-malate dehydrogenase activity (GO:0030060)
Orthologous Events
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Caenorhabditis elegans)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Canis familiaris)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Danio rerio)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Drosophila melanogaster)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Gallus gallus)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Mus musculus)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Plasmodium falciparum)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Rattus norvegicus)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Saccharomyces cerevisiae)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Schizosaccharomyces pombe)
Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ (Xenopus tropicalis)
oxaloacetate + NADH + H+ <=> malate + NAD+ (Gallus gallus)
Cross References
Rhea
Reviewed
Harris, RA  (2008-09-10)
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