Reactome | MDH2 reduces OA to MAL

MDH2 reduces OA to MAL

Stable Identifier

R-HSA-71783

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of carbohydrates (Homo sapiens)
  - Glucose metabolism (Homo sapiens)
    - Gluconeogenesis (Homo sapiens)
      - MDH2 reduces OA to MAL (Homo sapiens)
- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Citric acid cycle (TCA cycle) (Homo sapiens)
      - MDH2 reduces OA to MAL (Homo sapiens)

General

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Mitochondrial malate dehydrogenase (MDH2) catalyzes the reversible reaction of oxaloacetate (OA) and NADH + H+ to form malate (MAL) and NAD+ (Luo et al. 2006). The active enzyme is a homodimer (Sanchez et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
16740313	An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates Liu, J, Wang, X, Long, J, Luo, C	J Biochem Biophys Methods	2006
9792106	Aggregation states of mitochondrial malate dehydrogenase Hazlett, TL, Sanchez, SA, Jameson, DM, Brunet, JE	Protein Sci	1998