MDH2 reduces OA to MAL

Stable Identifier
R-HSA-71783
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
H(+) + NADH + oxaloacetate => (S)-malate + NAD(+)
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Mitochondrial malate dehydrogenase (MDH2) catalyzes the reversible reaction of oxaloacetate (OA) and NADH + H+ to form malate (MAL) and NAD+ (Luo et al. 2006). The active enzyme is a homodimer (Sanchez et al. 1998).

Literature References
PubMed ID Title Journal Year
16740313 An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates

Liu, J, Wang, X, Long, J, Luo, C

J Biochem Biophys Methods 2006
9792106 Aggregation states of mitochondrial malate dehydrogenase

Hazlett, TL, Sanchez, SA, Jameson, DM, Brunet, JE

Protein Sci 1998
Participants
Participates
Catalyst Activity

L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix]

Orthologous Events
Reviewed
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