acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]

Stable Identifier
R-HSA-71691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
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ALDH1A1 (aldehyde dehydrogenase) in the cytosol catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Inoue et al. 1979). The active form of the enzyme is a tetramer (Ni et al. 1999).

Literature References
PubMed ID Title Journal Year
10631996 Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms

Zhou, J, Hurley, TD, Ni, L, Weiner, H

Protein Sci 1999
224930 Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.

Yamasawa, K, Inoue, K, Nishimukai, H

Biochim Biophys Acta 1979
Participants
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Output
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as an event of
Catalyst Activity

aldehyde dehydrogenase (NAD+) activity of ALDH1A1 tetramer [cytosol]

Physical Entity
ALDH1A1 tetramer [cytosol] (Homo sapiens)
Activity
aldehyde dehydrogenase (NAD+) activity (GO:0004029)
Orthologous Events
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
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