acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]

Stable Identifier
R-HSA-71691
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

ALDH1A1 (aldehyde dehydrogenase) in the cytosol catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Inoue et al. 1979). The active form of the enzyme is a tetramer (Ni et al. 1999).

Literature References
PubMed ID Title Journal Year
224930 Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes.

Inoue, K, Nishimukai, H, Yamasawa, K

Biochim Biophys Acta 1979
10631996 Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms

Ni, L, Zhou, J, Hurley, TD, Weiner, H

Protein Sci 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

aldehyde dehydrogenase (NAD+) activity of ALDH1A1 tetramer [cytosol]

Physical Entity
ALDH1A1 tetramer [cytosol] (Homo sapiens)
Activity
aldehyde dehydrogenase (NAD+) activity (GO:0004029)
Orthologous Events
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Bos taurus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Caenorhabditis elegans)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Canis familiaris)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Dictyostelium discoideum)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Drosophila melanogaster)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Gallus gallus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Mus musculus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Rattus norvegicus)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Saccharomyces cerevisiae)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Schizosaccharomyces pombe)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Sus scrofa)
acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic] (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Cite Us!