Reactome | acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]

acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]

Stable Identifier

R-HSA-71691

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]

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ALDH1A1 (aldehyde dehydrogenase) in the cytosol catalyzes the reaction of acetaldehyde and NAD+ to form acetate and NADH + H+ (Inoue et al. 1979). The active form of the enzyme is a tetramer (Ni et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
10631996	Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms Ni, L, Zhou, J, Hurley, TD, Weiner, H	Protein Sci	1999
224930	Purification and partial characterization of aldehyde dehydrogenase from human erythrocytes. Inoue, K, Nishimukai, H, Yamasawa, K	Biochim Biophys Acta	1979