Reactome | 3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate

3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate

Stable Identifier

R-HSA-71654

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

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3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate

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Cytosolic phosphoglycerate mutase catalyzes the reversible isomerisation of 3- and 2-phosphoglycerate. The active form of the enzyme is a dimer. There are two isoforms of this enzyme, PGAM1 (isoform B, widely expressed in non-muscle tissue) and PGAM2 (isoform M, expressed in muscle) (Blouquit et al. 1988; Omenn and Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
4827367	Phosphoglycerate mutase isozyme marker for tissue differentiation in man Omenn, GS, Cheung, SC	Am J Hum Genet	1974
15710582	Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies Baso, MJR, Repiso, A, Climent, F, Corrons, J-LV, Carreras, J	Haematologica	2005
2846554	Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry Calvin, MC, Prome, JC, Rosa, R, Cohen-Solal, M, Prome, D, Blouquit, Y, Rosa, J, Pratbernou, F	J Biol Chem	1988
8447317	The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency Fenichel, G, Sakoda, S, Tsujino, S, DiMauro, S, Shanske, S	Am J Hum Genet	1993