Reactome | PGAM dimers isomerise 3PG to 2PG

PGAM dimers isomerise 3PG to 2PG

Stable Identifier

R-HSA-71654

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate

ReviewStatus

5/5

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Cytosolic phosphoglycerate mutase catalyzes the reversible isomerisation of 3- and 2-phosphoglycerate. The active form of the enzyme is a dimer. There are two isoforms of this enzyme, PGAM1 (isoform B, widely expressed in non-muscle tissue) and PGAM2 (isoform M, expressed in muscle) (Blouquit et al. 1988; Omenn and Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
4827367	Phosphoglycerate mutase isozyme marker for tissue differentiation in man Omenn, GS, Cheung, SC	Am J Hum Genet	1974
15710582	Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies Repiso, A, Baso, MJR, Corrons, J-LV, Carreras, J, Climent, F	Haematologica	2005
2846554	Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry Blouquit, Y, Calvin, MC, Rosa, R, Prome, D, Prome, JC, Pratbernou, F, Cohen-Solal, M, Rosa, J	J Biol Chem	1988
8447317	The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency Tsujino, S, Shanske, S, Sakoda, S, Fenichel, G, DiMauro, S	Am J Hum Genet	1993