Reactome | RPE dimers isomerise RU5P to XY5P

RPE dimers isomerise RU5P to XY5P

Stable Identifier

R-HSA-71303

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

D-ribulose 5-phosphate <=> xylulose 5-phosphate

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Cytosolic ribulose-5-phosphate-3-epimerase (RPE), using Fe2+ as cofactor, catalyzes the reversible interconversion of D-ribulose 5-phosphate (RU5P) and D-xylulose 5-phosphate (XY5P) (Bose & Pilz 1985, Liang et al. 2011). The electrophoretic properties of RPE activity detected in extracts of mouse-human somatic cell hybrids suggest that the active form of the enzyme is a homodimer (Spencer & Hopkinson 1980). Ribulose-phosphate 3-epimerase-like protein 1 (RPEL1), based on sequence similarity, is suggested to function as RPE.

Literature References

PubMed ID	Title	Journal	Year
2581946	Phosphoribosylpyrophosphate synthesis from glucose decreases during amino acid starvation of human lymphoblasts Pilz, RB, Boss, GR	J Biol Chem	1985
7396409	Biochemical genetics of the pentose phosphate cycle: human ribose 5-phosphate isomerase (RPI) and ribulose 5-phosphate 3-epimerase (RPE) Spencer, N, Hopkinson, DA	Ann Hum Genet	1980
20923965	Conversion of D-ribulose 5-phosphate to D-xylulose 5-phosphate: new insights from structural and biochemical studies on human RPE Shaw, N, Liu, ZJ, Ouyang, S, Zhang, R, Joachimiak, A, Liang, W	FASEB J.	2011