Reactome | ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

Stable Identifier

R-HSA-71260

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

4-(trimethylamino)butanal + H2O + NAD(+) = 4-(trimethylamino)butanoate + 2 H(+) + NADH, gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+

ReviewStatus

5/5

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ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

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Cytosolic 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) tetramer catalyzes the reaction of NAD+ and 4-trimethylammoniobutanal (TEABL) to form 4-trimethylammoniobutanoate (TEABT) and NADH + H+ (Koncitkova et al. 2019; Kurys et al. 1989; Vaz et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
30914451	Kinetic and structural analysis of human ALDH9A1 Moréra, S, Vigouroux, A, Šebela, M, Kopečná, M, Kopečný, D, Končitíková, R	Biosci Rep	2019
10702312	Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis. Vaz, FM, Fouchier, SW, Sommer, M, Ofman, R	J Biol Chem	2000
2925663	Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde. Ambroziak, W, Pietruszko, R, Kurys, G	J Biol Chem	1989