ALDH9A1 tetramer dehydrogenates TEABL to form TEABT

Stable Identifier
R-HSA-71260
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
4-(trimethylamino)butanal + H2O + NAD(+) => 4-(trimethylamino)butanoate + 2 H(+) + NADH, gamma-butyrobetaine semialdehyde + NAD+ => gamma-butyrobetaine + NADH + H+
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) tetramer catalyzes the reaction of NAD+ and 4-trimethylammoniobutanal (TEABL) to form 4-trimethylammoniobutanoate (TEABT) and NADH + H+ (Koncitkova et al. 2019; Kurys et al. 1989; Vaz et al. 2000).
Literature References
PubMed ID Title Journal Year
30914451 Kinetic and structural analysis of human ALDH9A1

Moréra, S, Vigouroux, A, Šebela, M, Kopečná, M, Kopečný, D, Končitíková, R

Biosci Rep 2019
10702312 Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.

Vaz, FM, Fouchier, SW, Sommer, M, Ofman, R

J Biol Chem 2000
2925663 Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde.

Ambroziak, W, Pietruszko, R, Kurys, G

J Biol Chem 1989
Participants
Participates
Catalyst Activity

4-trimethylammoniobutyraldehyde dehydrogenase activity of ALDH9A1 tetramer [cytosol]

Orthologous Events
Cross References
Rhea
Cite Us!