SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly

Stable Identifier
R-HSA-71249
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
beta-hydroxy-trimethyllysine => gamma-butyrobetaine aldehyde + glycine
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Cytosolic serine hydroxymethyltransferase tetramer (SHMT1) catalyzes the reaction of 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine (NTMLYS) to form glycine (Gly) and 4-trimethylammoniobutanal (TEABL) in vitro (Hulse et al. 1978). The possibility that an additional enzyme may catalyze this reaction in vivo has not been excluded (Bremer 1983).

Literature References
PubMed ID Title Journal Year
6361812 Carnitine--metabolism and functions

Bremer, J

Physiol. Rev. 1983
627563 Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase.

Hulse, JD, Ellis, SR, Henderson, LM

J Biol Chem 1978
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glycine hydroxymethyltransferase activity of SHMT1 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events