2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+

Stable Identifier
R-HSA-71239
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
2-aminomuconate 6-semialdehyde + H2O + NAD(+) => (2Z,4E)-2-aminomuconate + 2 H(+) + NADH
ReviewStatus
5/5
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2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
This reaction has been characterized in vitro using enzyme partially purified from cat liver (Ichiyama et al. 1965). The human event is inferred from the cat one. Neither the cat nor the human protein has been fully purified or sequenced.
Literature References
PubMed ID Title Journal Year
14275130 Studies on the metabolism of the benzene ring of tryptophan in mammalian tissues. II. Enzymatic formation of alpha-muconic acid from 2-hydroxyanthranilic acid

Ichiyama, A, Nakamura, S, Kawai, H, Honjo, T, Nishizuka, Y, Hayaishi, O, Senoh, S

J Biol Chem 1965
Participants
Input
Output
Participates
as an event of
Catalyst Activity

aminomuconate-semialdehyde dehydrogenase activity of AM-SHDH [cytosol]

Physical Entity
AM-SHDH [cytosol] (Homo sapiens)
Activity
aminomuconate-semialdehyde dehydrogenase activity (GO:0047102)
Inferred From
2-aminomuconate semialdehyde + NAD+ + H2O => aminomuconate + NADH + H+ (Felis catus)
Cross References
RHEA
Authored
D'Eustachio, P  (2005-07-20)
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