Reactome | 2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2

2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2

Stable Identifier

R-HSA-71223

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2

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At the beginning of this reaction, 1 molecule of '2-Amino-3-carboxymuconate semialdehyde' is present. At the end of this reaction, 1 molecule of 'CO2', and 1 molecule of '2-Aminomuconate semialdehyde' are present.

This reaction takes place in the 'cytoplasm' and is mediated by the 'carboxy-lyase activity' of '2-amino-3-carboxymuconate-6-semialdehyde decarboxylase homodimer'.

Literature References

PubMed ID	Title	Journal	Year
12140278	Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis". Fukuoka, S, Shibata, K, Tanabe, A, Egashira, Y, Yanagihara, K, Ishiguro, K, Sanada, H	J Biol Chem	2002