2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2

Stable Identifier
R-HSA-71223
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of '2-Amino-3-carboxymuconate semialdehyde' is present. At the end of this reaction, 1 molecule of 'CO2', and 1 molecule of '2-Aminomuconate semialdehyde' are present.

This reaction takes place in the 'cytoplasm' and is mediated by the 'carboxy-lyase activity' of '2-amino-3-carboxymuconate-6-semialdehyde decarboxylase homodimer'.

Literature References
PubMed ID Title Journal Year
12140278 Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".

Fukuoka, S, Ishiguro, K, Yanagihara, K, Tanabe, A, Egashira, Y, Sanada, H, Shibata, K

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
carboxy-lyase activity of ACMSD dimer [cytosol]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored