3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine

Stable Identifier
R-HSA-71217
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic kynureninase catalyzes the hydrolysis of 3-hydroxy-L-kynurenine to form L-alanine and 3-hydroxyanthranilate.
Literature References
PubMed ID Title Journal Year
9180257 Cloning and recombinant expression of rat and human kynureninase.

Gatti, S, Benatti, L, Speciale, C, Mostardini, M, Avanzi, N, Cozzi, L, Kido, R, Breton, J, Okuno, E, Toné, S, Toma, S, Nakamura, M

FEBS Lett 1997
Participants
Input
Output
Participates
as an event of
Catalyst Activity

kynureninase activity of KYNU dimer [cytosol]

Physical Entity
KYNU dimer [cytosol] (Homo sapiens)
Activity
kynureninase activity (GO:0030429)
Orthologous Events
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Bos taurus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Caenorhabditis elegans)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Canis familiaris)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Dictyostelium discoideum)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Gallus gallus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Mus musculus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Rattus norvegicus)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Saccharomyces cerevisiae)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Sus scrofa)
3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2005-07-20)
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