TDO tetramer dioxygenates L-Trp to NFK

Stable Identifier
R-HSA-71188
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
tryptophan + O2 => N-formylkynurenine [TDO]
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Cytosolic tryptophan 2,3-dioxygenase (TDO) tetramer catalyzes the conversion of L-tryptophan and oxygen to formylkynurenine. The structure and catalytic properties of the human enzyme are inferred from the close similarity of its predicted amino acid sequence (Comings et al. 1995) to that of the well-studied rat enzyme (Dick et al. 2001). In the body, TDO is found predominantly in the liver and is induced by metabolites such as tryptophan and histidine, and by glucocorticoids. These properties, together with TDO's narrow substrate specificity, are consistent with the hypothesis that the enzyme functions functions primarily in tryptophan catabolism and NAD biosynthesis (Taylor and Feng 1991).

Literature References
PubMed ID Title Journal Year
8666386 Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat

Comings, DE, Dietz, G, Forest, GL, Muhleman, D, Sherman, M

Genomics 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
tryptophan 2,3-dioxygenase activity of TDO2 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored