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HPD [cytosol]
Stable Identifier
R-HSA-71159
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
4-hydroxyphenylpyruvate dioxygenase, 4HPPD, HPPDase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Phenylalanine and tyrosine metabolism (Homo sapiens)
Tyrosine catabolism (Homo sapiens)
HPD dioxygenates HPP (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
HPD [cytosol] (Homo sapiens)
nitisinone:HPD dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ dimer [cytosol] (Homo sapiens)
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
HPD [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P32754 HPD
Gene Names
HPD, PPD
Chain
initiator methionine:, chain:2-393
Reference Genes
BioGPS Gene:3242 HPD
COSMIC (genes):HPD HPD
CTD Gene:3242 HPD
dbSNP Gene:3242 HPD
ENSEMBL:ENSG00000158104 HPD
HGNC:5147 HPD
KEGG:hsa:3242 HPD
Monarch:3242 HPD
NCBI Gene:3242 HPD
OMIM:609695 HPD
UCSC:P32754 HPD
Reference Transcript
RefSeq:NM_001171993.1 HPD
RefSeq:NM_002150.2 HPD
Other Identifiers
11727840_at
16771602
206024_PM_at
206024_at
3242
33487_at
3475384
3475385
3475387
3475388
3475389
3475390
3475391
3475392
3475393
3475394
3475395
3475396
3475397
3475398
3475399
3475400
3475401
50649_s_at
7967212
A_23_P139527
D31628_s_at
GE57162
GO:0000139
GO:0003824
GO:0003868
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0006520
GO:0006559
GO:0006572
GO:0009072
GO:0016020
GO:0016491
GO:0016701
GO:0042803
GO:0043226
GO:0046872
GO:0051213
GO:0070062
ILMN_1745688
PH_hs_0028717
TC12002066.hg
g4504476_3p_at
Participates
as a component of
HPD:AscH-:Fe2+ [cytosol] (Homo sapiens)
Inferred To
HPD [cytosol]
(Bos taurus)
HPD [cytosol]
(Caenorhabditis elegans)
HPD [cytosol]
(Canis familiaris)
HPD [cytosol]
(Danio rerio)
HPD [cytosol]
(Dictyostelium discoideum)
HPD [cytosol]
(Drosophila melanogaster)
HPD [cytosol]
(Gallus gallus)
HPD [cytosol]
(Mus musculus)
HPD [cytosol]
(Rattus norvegicus)
HPD [cytosol]
(Sus scrofa)
HPD [cytosol]
(Xenopus tropicalis)
Homologues of HPD [cytosol]
(Caenorhabditis elegans)
Homologues of HPD [cytosol]
(Dictyostelium discoideum)
Cross References
Guide to Pharmacology - Targets
2621
ENSEMBL
ENST00000543163
,
ENSG00000158104
,
ENSP00000441677
OpenTargets
ENSG00000158104
ZINC - FDA approved
HPPD_HUMAN
ZINC - Substances
HPPD_HUMAN
ZINC target
P32754
PRO
P32754
PDB
3ISQ
,
8IM3
,
8IM2
,
5EC3
GeneCards
HPD
HPA
ENSG00000158104-HPD
Pharos - Targets
P32754
Orphanet
HPD
ZINC - Predictions - Purchasable
HPPD_HUMAN
HMDB Protein
HMDBP00841
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