Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PAH [cytosol]
Stable Identifier
R-HSA-71066
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phenylalanine hydroxylase apoprotein monomer, phenylalanine-4-hydroxylase, PH4H_HUMAN, Phenylalanine-4-hydroxylase , Phe-4- monooxygenase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer [cytosol] (Homo sapiens)
PAH [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00439 PAH
Gene Names
PAH
Chain
chain:1-452
Reference Genes
BioGPS Gene:5053 PAH
COSMIC (genes):PAH PAH
CTD Gene:5053 PAH
dbSNP Gene:5053 PAH
ENSEMBL:ENSG00000171759 PAH
ENSEMBL_homo_sapiens_GENE:ENSG00000171759.10 PAH
HGNC:8582 PAH
KEGG Gene (Homo sapiens):5053 PAH
Monarch:5053 PAH
NCBI Gene:5053 PAH
OMIM:612349 PAH
UCSC:P00439 PAH
Reference Transcript
RefSeq:NM_000277.1 PAH
Other Identifiers
11744206_at
11753066_a_at
205719_PM_s_at
205719_s_at
217583_PM_at
217583_at
242375_PM_x_at
242375_x_at
33701_at
3468477
3468478
3468479
3468480
3468481
3468482
3468483
3468484
3468486
3468492
3468493
3468494
3468497
3468501
3468504
3468506
3468511
3468522
3468531
3468533
3468534
4052199
4053738
5053
7965884
82891_at
A_23_P2501
A_32_P226169
GE59205
GO:0003824
GO:0004497
GO:0004505
GO:0005506
GO:0005829
GO:0006520
GO:0006559
GO:0006571
GO:0008152
GO:0008652
GO:0009072
GO:0016491
GO:0016714
GO:0019293
GO:0042423
GO:0046872
HMNXSV003038266
Hs.297257.0.A1_3p_at
ILMN_1662214
ILMN_1824490
ILMN_2218104
L47726_at
PH_hs_0023809
TC12001892.hg
g4557818_3p_s_at
Participates
as a component of
PAH:Fe2+ tetramer [cytosol] (Homo sapiens)
Other forms of this molecule
PAH S40L [cytosol]
Inferred To
Ghost homologue of PAH [cytosol]
(Xenopus tropicalis)
PAH [cytosol]
(Bos taurus)
PAH [cytosol]
(Caenorhabditis elegans)
PAH [cytosol]
(Canis familiaris)
PAH [cytosol]
(Danio rerio)
PAH [cytosol]
(Dictyostelium discoideum)
PAH [cytosol]
(Drosophila melanogaster)
PAH [cytosol]
(Gallus gallus)
PAH [cytosol]
(Mus musculus)
PAH [cytosol]
(Rattus norvegicus)
PAH [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_000268.1
Guide to Pharmacology - Targets
1240
OpenTargets
ENSG00000171759
ZINC - Substances
PH4H_HUMAN
ZINC target
P00439
PRO
P00439
PDB
4PAH
,
1J8U
,
4ANP
,
1DMW
,
6HPO
,
1PAH
,
1J8T
,
6HYC
,
1MMK
,
6N1K
,
1LRM
,
5PAH
,
5FII
,
3PAH
,
1KW0
,
2PAH
,
1MMT
,
1TG2
,
6PAH
,
1TDW
HPA
ENSG00000171759-PAH
GeneCards
P00439
Ensembl
ENST00000553106
,
ENSP00000448059
,
ENSG00000171759
Pharos - Targets
P00439
ZINC - Predictions - Purchasable
PH4H_HUMAN
Orphanet
16605
HMDB Protein
HMDBP00280
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text