Reactome | PAH [cytosol]

PAH [cytosol]

Stable Identifier

R-HSA-71066

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phenylalanine hydroxylase apoprotein monomer, phenylalanine-4-hydroxylase, PH4H_HUMAN, Phenylalanine-4-hydroxylase , Phe-4- monooxygenase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P00439 PAH

Gene Names

PAH

Chain

chain:1-452

Reference Genes

BioGPS Gene:5053 PAH

COSMIC (genes):PAH PAH

CTD Gene:5053 PAH

dbSNP Gene:5053 PAH

ENSEMBL:ENSG00000171759 PAH

ENSEMBL_homo_sapiens_GENE:ENSG00000171759.10 PAH

HGNC:8582 PAH

KEGG Gene (Homo sapiens):5053 PAH

Monarch:5053 PAH

NCBI Gene:5053 PAH

OMIM:612349 PAH

UCSC:P00439 PAH

Reference Transcript

RefSeq:NM_000277.1 PAH

Other Identifiers

11744206_at

11753066_a_at

205719_PM_s_at

205719_s_at

217583_PM_at

217583_at

242375_PM_x_at

242375_x_at

33701_at

3468477

3468478

3468479

3468480

3468481

3468482

3468483

3468484

3468486

3468492

3468493

3468494

3468497

3468501

3468504

3468506

3468511

3468522

3468531

3468533

3468534

4052199

4053738

5053

7965884

82891_at

A_23_P2501

A_32_P226169

GE59205

GO:0003824

GO:0004497

GO:0004505

GO:0005506

GO:0005829

GO:0006520

GO:0006559

GO:0006571

GO:0008152

GO:0008652

GO:0009072

GO:0016491

GO:0016714

GO:0019293

GO:0042423

GO:0046872

HMNXSV003038266

Hs.297257.0.A1_3p_at

ILMN_1662214

ILMN_1824490

ILMN_2218104

L47726_at

PH_hs_0023809

TC12001892.hg

g4557818_3p_s_at

Participates

as a component of

PAH:Fe2+ tetramer [cytosol] (Homo sapiens)

Other forms of this molecule

PAH S40L [cytosol]

Inferred To

Ghost homologue of PAH [cytosol] (Xenopus tropicalis)

PAH [cytosol] (Bos taurus)

PAH [cytosol] (Caenorhabditis elegans)

PAH [cytosol] (Canis familiaris)

PAH [cytosol] (Danio rerio)

PAH [cytosol] (Dictyostelium discoideum)

PAH [cytosol] (Drosophila melanogaster)

PAH [cytosol] (Gallus gallus)

PAH [cytosol] (Mus musculus)

PAH [cytosol] (Rattus norvegicus)

PAH [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_000268.1

Guide to Pharmacology - Targets

1240

OpenTargets

ENSG00000171759

ZINC - Substances

PH4H_HUMAN

ZINC target

P00439

PRO

P00439

PDB

1LRM, 6HYC, 6N1K, 1PAH, 5PAH, 4ANP, 2PAH, 5FII, 1MMK, 1TG2, 4PAH, 3PAH, 1J8T, 1DMW, 6PAH, 1KW0, 1J8U, 1TDW, 1MMT, 6HPO

GeneCards

P00439

HPA

ENSG00000171759-PAH

Ensembl

ENSG00000171759, ENSP00000448059, ENST00000553106

Pharos - Targets

P00439

Orphanet

16605

ZINC - Predictions - Purchasable

PH4H_HUMAN

HMDB Protein

HMDBP00280

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