Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA

Stable Identifier
Reaction [transition]
Homo sapiens
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Mitochondrial citrate synthase dimer catalyzes the irreversible reaction of acetyl-CoA, water, and oxaloacetate to form citrate and coenzyme A. This reaction is the entry point of two-carbon units into the citric acid cycle. The reaction is subject to allosteric regulation. The gene encoding the human enzyme has been cloned (Goldenthal et al. 1998), but the enzyme has not been characterized in detail - its properties are inferred from those of the well-studied homologous pig enzyme (e.g., Morgunov and Srere 1998).

Literature References
PubMed ID Title Journal Year
9809442 Cloning and molecular analysis of the human citrate synthase gene

Marin-Garcia, J, Ananthakrishnan, R, Goldenthal, MJ

Genome 1998
9792662 Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate

Morgunov, I, Srere, PA

J Biol Chem 1998
Catalyst Activity

citrate (Si)-synthase activity of CS dimer [mitochondrial matrix]

Orthologous Events
Cross References
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