Mitochondrial isocitrate dehydrogenase IDH3 catalyzes the irreversible reaction of isocitrate and NAD+ to form alpha ketoglutarate, CO2, and NADH + H+. The enzyme is a heteromer containing four polypeptide chains, two IDH3A, one IDH3B, and one IDH3G, and two Mn++ (Dange and Colman 2010). It is activated by ADP (Soundar et al. 2003, 2006; Bzymek and Colman 2007). This is the first of four oxidation reactions in the citric acid cycle, and the first decarboxylation.
O'Hagan, M, Fomulu, KS, Colman, RF, Soundar, S
Bzymek, KP, Colman, RF
Dange, M, Colman, RF
Park, JH, Colman, RF, Soundar, S
isocitrate dehydrogenase (NAD+) activity of IDH3 complex [mitochondrial matrix]
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