Reactome | alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

Stable Identifier

R-HSA-70941

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

(S)-2-amino-6-oxohexanoate + H2O + NAD(+) => 2 H(+) + L-2-aminoadipate + NADH

ReviewStatus

5/5

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alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

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Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
19885858	Is antiquitin a mitochondrial Enzyme? Wong, JW, Chan, CL, Tang, WK, Cheng, CH, Fong, WP	J Cell Biochem	2010
16491085	Mutations in antiquitin in individuals with pyridoxine-dependent seizures Mills, PB, Struys, E, Jakobs, C, Plecko, B, Baxter, P, Baumgartner, M, Willemsen, MA, Omran, H, Tacke, U, Uhlenberg, B, Weschke, B, Clayton, PT	Nat Med	2006