Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).
Fong, WP, Tang, WK, Wong, JW, Chan, CL, Cheng, CH
Struys, E, Mills, PB, Willemsen, MA, Baumgartner, M, Baxter, P, Uhlenberg, B, Clayton, PT, Weschke, B, Tacke, U, Plecko, B, Jakobs, C, Omran, H
L-aminoadipate-semialdehyde dehydrogenase activity of ALDH7A1 tetramer [mitochondrial matrix]
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