alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

Stable Identifier
R-HSA-70941
Type
Reaction
Species
Homo sapiens
Compartment
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Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).

Literature References
PubMed ID Title Journal Year
19885858 Is antiquitin a mitochondrial Enzyme?

Fong, WP, Tang, WK, Wong, JW, Chan, CL, Cheng, CH

J Cell Biochem 2010
16491085 Mutations in antiquitin in individuals with pyridoxine-dependent seizures

Struys, E, Mills, PB, Willemsen, MA, Baumgartner, M, Baxter, P, Uhlenberg, B, Clayton, PT, Weschke, B, Tacke, U, Plecko, B, Jakobs, C, Omran, H

Nat Med 2006
Participants
Participates
Catalyst Activity

L-aminoadipate-semialdehyde dehydrogenase activity of ALDH7A1 tetramer [mitochondrial matrix]

Orthologous Events
Cross References
Rhea
Authored
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