Reactome | urocanate + H2O => 4-imidazolone-5-propionate

urocanate + H2O => 4-imidazolone-5-propionate

Stable Identifier

R-HSA-70903

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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urocanate + H2O => 4-imidazolone-5-propionate

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Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19304569	Mutations in the urocanase gene UROC1 are associated with urocanic aciduria Vilaseca, MA, Palau, F, Espinós, C, Spaapen, LJ, Martinez-Rubio, D, Artuch, R, Ormazabal, A, Lupo, V, Pineda, M	J Med Genet	2009
15221005	Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas Kaneko, M, Yamada, S, Ohnuma, N, Suita, S, Suzuki, Y, Hirata, T, Nakagawara, A, Horie, H, Ando, H, Ando, K, Sasaki, F, Hayashi, Y, Sugano, S, Goto, T, Takayasu, H, Ohira, M, Matsunaga, T, Hashizume, K, Hiyama, E	Oncogene	2004