beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA

Stable Identifier
R-HSA-70881
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
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beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
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Mitochondrial 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) catalyzes the hydrolysis of beta-hydroxyisobutyryl-CoA to form beta-hydroxyisobutyrate (3-hydroxy-2-methylpropanoate) and CoA (Hawes et al. 1996).

Literature References
PubMed ID Title Journal Year
8824301 Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase.

Bunting, J, Harper, ET, Harris, RA, Shimomura, Y, Huang, B, Hawes, JW, Jaskiewicz, J

J Biol Chem 1996
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Catalyst Activity

3-hydroxyisobutyryl-CoA hydrolase activity of HIBCH [mitochondrial matrix]

Physical Entity
HIBCH [mitochondrial matrix] (Homo sapiens)
Activity
3-hydroxyisobutyryl-CoA hydrolase activity (GO:0003860)
Orthologous Events
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Gallus gallus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)
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