beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA

Stable Identifier
R-HSA-70881
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) catalyzes the hydrolysis of beta-hydroxyisobutyryl-CoA to form beta-hydroxyisobutyrate (3-hydroxy-2-methylpropanoate) and CoA (Hawes et al. 1996).

Literature References
PubMed ID Title Journal Year
8824301 Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase.

Bunting, J, Harper, ET, Harris, RA, Shimomura, Y, Huang, B, Hawes, JW, Jaskiewicz, J

J Biol Chem 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

3-hydroxyisobutyryl-CoA hydrolase activity of HIBCH [mitochondrial matrix]

Physical Entity
HIBCH [mitochondrial matrix] (Homo sapiens)
Activity
3-hydroxyisobutyryl-CoA hydrolase activity (GO:0003860)
Orthologous Events
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Bos taurus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Caenorhabditis elegans)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Canis familiaris)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Danio rerio)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Dictyostelium discoideum)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Drosophila melanogaster)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Gallus gallus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Mus musculus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Plasmodium falciparum)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Rattus norvegicus)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Saccharomyces cerevisiae)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Schizosaccharomyces pombe)
beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (Sus scrofa)
Cite Us!