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ACAD8 [mitochondrial matrix]
Stable Identifier
R-HSA-70855
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
isobutyryl-CoA dehydrogenase, acyl-CoA dehydrogenase family member 8, Acyl-CoA dehydrogenase family member 8, mitochondrial precursor , Activator- recruited cofactor 42 kDa component, ARC42
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2 (Homo sapiens)
ACAD8 tetramer [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
LONP1 binds mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
LONP1 degrades mitochondrial matrix proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
ACAD8 [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
14752098
Structures of isobutyryl-CoA dehydrogenase and enzyme-product complex: comparison with isovaleryl- and short-chain acyl-CoA dehydrogenases
Kim, JJ
,
Battaile, KP
,
Vockley, J
,
Nguyen, TV
J Biol Chem
2004
External Reference Information
External Reference
UniProt:Q9UKU7 ACAD8
Gene Names
ACAD8, ARC42, IBD
Chain
transit peptide:1-22, chain:23-415
Reference Genes
BioGPS Gene:27034 ACAD8
COSMIC (genes):ACAD8 ACAD8
CTD Gene:27034 ACAD8
dbSNP Gene:27034 ACAD8
ENSEMBL:ENSG00000151498 ACAD8
HGNC:87 ACAD8
KEGG:hsa:27034 ACAD8
Monarch:27034 ACAD8
NCBI Gene:27034 ACAD8
OMIM:604773 ACAD8
UCSC:Q9UKU7 ACAD8
Reference Transcript
RefSeq:NM_014384.2 ACAD8
Other Identifiers
11746914_a_at
11746915_x_at
11747492_a_at
11754333_a_at
11760930_at
11761018_a_at
16733660
221669_PM_s_at
221669_s_at
27034
3357304
3357305
3357308
3357309
3357310
3357311
3357312
3357313
3357314
3357315
3357316
3357317
3357318
3357319
3357320
3357321
3357322
3357323
3357324
3357325
3357326
3357327
3357328
3357329
3357330
3357331
3357332
3357333
3357334
3357335
3357336
3357337
3357338
3357339
54278_at
63383_at
77945_at
7945283
A_14_P127434
A_24_P4678
GE58588
GO:0003824
GO:0003995
GO:0005515
GO:0005739
GO:0005759
GO:0006520
GO:0006574
GO:0006629
GO:0009083
GO:0016491
GO:0016627
GO:0043226
GO:0050660
HMNXSV003010751
HMNXSV003023126
ILMN_2225595
PH_hs_0001397
TC11001215.hg
g12805020_3p_a_at
Participates
as a member of
Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
ACAD8 tetramer [mitochondrial matrix] (Homo sapiens)
Inferred To
ACAD8 [mitochondrial matrix]
(Bos taurus)
ACAD8 [mitochondrial matrix]
(Canis familiaris)
ACAD8 [mitochondrial matrix]
(Dictyostelium discoideum)
ACAD8 [mitochondrial matrix]
(Gallus gallus)
ACAD8 [mitochondrial matrix]
(Mus musculus)
ACAD8 [mitochondrial matrix]
(Sus scrofa)
acdh-9 [mitochondrial matrix]
(Caenorhabditis elegans)
Acad8 [mitochondrial matrix]
(Rattus norvegicus)
acad8 [mitochondrial matrix]
(Danio rerio)
acad8 [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_055199.1
ENSEMBL
ENST00000281182
,
ENSP00000281182
,
ENST00000374752
,
ENSP00000363884
,
ENSG00000151498
OpenTargets
ENSG00000151498
GeneCards
ACAD8
HPA
ENSG00000151498-ACAD8
PRO
Q9UKU7
Pharos - Targets
Q9UKU7
Orphanet
ACAD8
HMDB Protein
HMDBP05273
PDB
1RX0
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