alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA

Stable Identifier
R-HSA-70844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose aminoterminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).
Literature References
PubMed ID Title Journal Year
17371050 Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function

Kondo, N, Haapalainen, AM, Fukao, T, Pirilä, PL, Wierenga, RK, Meriläinen, G

Biochemistry 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]

Physical Entity
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
acetyl-CoA C-acetyltransferase activity (GO:0003985)
Orthologous Events
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Gallus gallus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)
alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)
Cross References
Rhea
Cite Us!