alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA

Stable Identifier
R-HSA-70844
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
2-methyl-3-oxobutanoyl-CoA + CoA => acetyl-CoA + propanoyl-CoA
ReviewStatus
5/5
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alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA
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Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose amino-terminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).
Literature References
PubMed ID Title Journal Year
17371050 Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function

Kondo, N, Haapalainen, AM, Fukao, T, Pirilä, PL, Wierenga, RK, Meriläinen, G

Biochemistry 2007
Participants
Input
Output
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as an event of
Catalyst Activity

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]

Physical Entity
ACAT1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
acetyl-CoA C-acetyltransferase activity (GO:0003985)
Orthologous Events
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Bos taurus)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Caenorhabditis elegans)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Canis familiaris)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Danio rerio)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Dictyostelium discoideum)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Drosophila melanogaster)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Gallus gallus)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Mus musculus)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Plasmodium falciparum)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Rattus norvegicus)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Sus scrofa)
alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA (Xenopus tropicalis)
Cross References
RHEA
Rhea
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