Mitochondrial acetyl-CoA acetyltransferase (ACAT1) catalyzes the reaction of alpha-methyl-acetoacetyl-CoA and CoA to form propionyl-CoA and acetyl-CoA. Structural studies have shown the active enzyme to be a tetramer of ACAT1 polypeptides whose aminoterminal 34 residues, a mitochondrial targeting sequence, have been removed (Haapalainen et al. 2007).
Kondo, N, Haapalainen, AM, Fukao, T, Pirilä, PL, Wierenga, RK, Meriläinen, G
acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
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