tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA

Stable Identifier
R-HSA-70830
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
(2E)-2-methylbut-2-enoyl-CoA + H2O => (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA
ReviewStatus
5/5
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tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA
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Mitochondrial tiglyl-CoA is hydrolyzed to form alpha-methyl-beta-hydroxybutyryl-CoA. While crude extracts of human liver cells have been shown to catalyze the reaction, the specific enzyme responsible for it has not been identified (Sweetman and Williams 2001).
Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed

Scriver, CR, Beaudet, AL, Valle, D, Sly, WS

  2001
Participants
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Output
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as an event of
Catalyst Activity

enoyl-CoA hydratase activity of enoyl-CoA hydratase [mitochondrial matrix]

Physical Entity
enoyl-CoA hydratase [mitochondrial matrix] (Homo sapiens)
Activity
enoyl-CoA hydratase activity (GO:0004300)
Cross References
RHEA
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