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GLS2 [mitochondrial matrix]
Stable Identifier
R-HSA-70610
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
glutaminase 2, Glutaminase, liver isoform, mitochondrial precursor
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
TP53 stimulates GLS2 transcription (Homo sapiens)
GLS2 dimer [mitochondrial matrix] (Homo sapiens)
GLS2 [mitochondrial matrix] (Homo sapiens)
glutamine + H2O => glutamate + NH4+ (GLS) (Homo sapiens)
GLS dimers [mitochondrial matrix] (Homo sapiens)
GLS2 dimer [mitochondrial matrix] (Homo sapiens)
GLS2 [mitochondrial matrix] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glutamate and glutamine metabolism (Homo sapiens)
glutamine + H2O => glutamate + NH4+ (GLS) (Homo sapiens)
GLS dimers [mitochondrial matrix] (Homo sapiens)
GLS2 dimer [mitochondrial matrix] (Homo sapiens)
GLS2 [mitochondrial matrix] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
glutamine + H2O => glutamate + NH4+ (GLS) (Homo sapiens)
GLS dimers [mitochondrial matrix] (Homo sapiens)
GLS2 dimer [mitochondrial matrix] (Homo sapiens)
GLS2 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UI32 GLS2
Gene Names
GLS2, GA
Chain
transit peptide:1-14, chain:15-602
Reference Genes
BioGPS Gene:27165 GLS2
COSMIC (genes):GLS2 GLS2
CTD Gene:27165 GLS2
dbSNP Gene:27165 GLS2
ENSEMBL:ENSG00000135423 GLS2
HGNC:29570 GLS2
KEGG:hsa:27165 GLS2
Monarch:27165 GLS2
NCBI Gene:27165 GLS2
OMIM:606365 GLS2
UCSC:Q9UI32 GLS2
Reference Transcript
RefSeq:NM_013267.3 GLS2
RefSeq:NM_001280798.1 GLS2
Other Identifiers
11747633_a_at
11753078_a_at
11756498_a_at
11762122_a_at
11762123_at
11762124_x_at
1564705_3p_at
1564705_PM_at
1564705_at
1564706_PM_s_at
1564706_s_at
1564707_PM_x_at
1564707_x_at
16766185
205531_PM_s_at
205531_s_at
27165
3457888
3457890
3457892
3457893
3457894
3457895
3457896
3457897
3457898
3457899
3457900
3457901
3457902
3457903
3457904
3457905
3457906
3457907
3457908
3457909
3457910
3457911
3457912
3457913
3457914
3457915
3457916
3457917
3457918
3457919
3457920
3457922
3457923
3457924
3457925
35711_at
71127_at
7964183
A_24_P326739
GE552452
GE58509
GE897803
GO:0003824
GO:0004359
GO:0005515
GO:0005739
GO:0005759
GO:0006520
GO:0006537
GO:0006541
GO:0006543
GO:0016787
GO:0042981
GO:0043226
GO:0072593
HMNXSV003001445
Hs2.381364.1.S1_3p_x_at
ILMN_1677439
ILMN_1706070
PH_hs_0023088
TC12001607.hg
g7019388_3p_a_at
Participates
as a component of
GLS2 dimer [mitochondrial matrix] (Homo sapiens)
Inferred To
gls2 [mitochondrial matrix]
(Xenopus tropicalis)
glna-1 [mitochondrial matrix]
(Caenorhabditis elegans)
GLS2 [mitochondrial matrix]
(Bos taurus)
GLS2 [mitochondrial matrix]
(Canis familiaris)
GLS2 [mitochondrial matrix]
(Sus scrofa)
Gls [mitochondrial matrix]
(Drosophila melanogaster)
glsl [mitochondrial matrix]
(Danio rerio)
Gls2 [mitochondrial matrix]
(Mus musculus)
Gls2 [mitochondrial matrix]
(Rattus norvegicus)
Cross References
RefSeq
NP_037399.2
,
NP_001267727.1
ENSEMBL
ENST00000486896
,
ENSG00000135423
,
ENST00000311966
,
ENSP00000310447
,
ENSP00000419661
OpenTargets
ENSG00000135423
IntEnz
3.5.1.2
GeneCards
GLS2
HPA
ENSG00000135423-GLS2
PRO
Q9UI32
Pharos - Targets
Q9UI32
HMDB Protein
HMDBP00675
PDB
4BQM
,
8T0Z
,
5U0K
,
8SZL
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6GPH4 XAF1
1
XAF1 [cytosol]
(R-HSA-1015680)
0.556
3
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