GOT2 dimer deaminates L-Asp

Stable Identifier
R-HSA-70596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
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GOT2 dimer deaminates L-Asp
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Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate and 2-oxoglutarate (alpha-ketoglutarate) to form oxaloacetate and glutamate (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Martini, F, Angelaccio, S, Barra, D, Pascarella, S, Maras, B, Doonan, S, Bossa, F

Biochim Biophys Acta 1985
Participants
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Participant Of
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Event Information
Reverse Reaction
oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2] (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
Physical Entity
GOT2 dimer [mitochondrial matrix]
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (0004069)
Orthologous Events
GOT2 dimer deaminates L-Asp (Bos taurus)
GOT2 dimer deaminates L-Asp (Caenorhabditis elegans)
GOT2 dimer deaminates L-Asp (Canis familiaris)
GOT2 dimer deaminates L-Asp (Danio rerio)
GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)
GOT2 dimer deaminates L-Asp (Drosophila melanogaster)
GOT2 dimer deaminates L-Asp (Mus musculus)
GOT2 dimer deaminates L-Asp (Plasmodium falciparum)
GOT2 dimer deaminates L-Asp (Rattus norvegicus)
GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)
GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)
GOT2 dimer deaminates L-Asp (Xenopus tropicalis)
Cross References
Rhea
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