GOT2 dimer transaminates L-Asp

Stable Identifier
R-HSA-70596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
2-oxoglutarate + L-aspartate => L-glutamate + oxaloacetate, aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
ReviewStatus
5/5
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GOT2 dimer transaminates L-Asp
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Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) to form oxaloacetate (OA) and glutamate (L-Glu) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.
Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Martini, F, Angelaccio, S, Barra, D, Pascarella, S, Maras, B, Doonan, S, Bossa, F

Biochim Biophys Acta 1985
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Event Information
Reverse Reaction
GOT2 transaminates OA and L-Glu (Homo sapiens)
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]

Physical Entity
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Orthologous Events
GOT2 dimer transaminates L-Asp (Bos taurus)
GOT2 dimer transaminates L-Asp (Caenorhabditis elegans)
GOT2 dimer transaminates L-Asp (Canis familiaris)
GOT2 dimer transaminates L-Asp (Danio rerio)
GOT2 dimer transaminates L-Asp (Dictyostelium discoideum)
GOT2 dimer transaminates L-Asp (Drosophila melanogaster)
GOT2 dimer transaminates L-Asp (Gallus gallus)
GOT2 dimer transaminates L-Asp (Mus musculus)
GOT2 dimer transaminates L-Asp (Rattus norvegicus)
GOT2 dimer transaminates L-Asp (Saccharomyces cerevisiae)
GOT2 dimer transaminates L-Asp (Schizosaccharomyces pombe)
GOT2 dimer transaminates L-Asp (Sus scrofa)
GOT2 dimer transaminates L-Asp (Xenopus tropicalis)
Cross References
RHEA
Rhea
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