GOT2 dimer deaminates L-Asp

Stable Identifier
R-HSA-70596
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GOT2 dimer deaminates L-Asp
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Mitochondrial glutamate oxaloacetate transaminase 2 (aspartate aminotransferase 2 - GOT2) catalyzes the reversible reaction of aspartate (L-Asp) and 2-oxoglutarate (2OG, alpha-ketoglutarate) to form oxaloacetate (OA) and glutamate (L-Glu) (Martini et al. 1985). The active form of the enzyme is inferred to be a dimer with one molecule of pyridoxal phosphate associated with each monomer.

Literature References
PubMed ID Title Journal Year
4052435 The primary structure of mitochondrial aspartate aminotransferase from human heart

Bossa, F, Maras, B, Barra, D, Pascarella, S, Angelaccio, S, Doonan, S, Martini, F

Biochim Biophys Acta 1985
Participants
Input
Output
Participates
as an event of
Event Information
Reverse Reaction
GOT2 transaminates oxaloacetate and glutamate (Homo sapiens)
Catalyst Activity

L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]

Physical Entity
GOT2 dimer [mitochondrial matrix] (Homo sapiens)
Activity
L-aspartate:2-oxoglutarate aminotransferase activity (GO:0004069)
Orthologous Events
GOT2 dimer deaminates L-Asp (Bos taurus)
GOT2 dimer deaminates L-Asp (Caenorhabditis elegans)
GOT2 dimer deaminates L-Asp (Canis familiaris)
GOT2 dimer deaminates L-Asp (Danio rerio)
GOT2 dimer deaminates L-Asp (Dictyostelium discoideum)
GOT2 dimer deaminates L-Asp (Drosophila melanogaster)
GOT2 dimer deaminates L-Asp (Gallus gallus)
GOT2 dimer deaminates L-Asp (Mus musculus)
GOT2 dimer deaminates L-Asp (Plasmodium falciparum)
GOT2 dimer deaminates L-Asp (Rattus norvegicus)
GOT2 dimer deaminates L-Asp (Saccharomyces cerevisiae)
GOT2 dimer deaminates L-Asp (Schizosaccharomyces pombe)
GOT2 dimer deaminates L-Asp (Sus scrofa)
Cross References
Rhea
Cite Us!